ArticleApplied and environmental microbiology2006
Overexpression of the 14alpha-demethylase target gene (CYP51) mediates fungicide resistance in Blumeriella jaapii.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed.
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- Differential Impact of Ergosterol on Yeast Membranes Exposed to Membrane-Targeting Antimicrobial Compounds.Chembiochem : a European journal of chemical biology · 2026Article
- Exploring the Molecular Mechanisms of Resistance to Prochloraz byJournal of fungi (Basel, Switzerland) · 2024Article
- Cyclo(Pro-Tyr) elicits conserved cellular damage in fungi by targeting the [HCommunications biology · 2024Article
- Multiple routes to fungicide resistance: Interaction of Cyp51 gene sequences, copy number and expression.Molecular plant pathology · 2024Article
- Transcriptome Analysis Reveals Potential Regulators of DMI Fungicide Resistance in the Citrus Postharvest PathogenJournal of fungi (Basel, Switzerland) · 2024Article
- Dose-Dependent Genetic Resistance to Azole Fungicides Found in the Apple Scab Pathogen.Journal of fungi (Basel, Switzerland) · 2023Article
- Sensitivity Baselines, Resistance Monitoring, and Molecular Mechanisms of the Rice False Smut PathogenJournal of fungi (Basel, Switzerland) · 2023Article
- In Vitro Evaluation of Azoxystrobin, Boscalid, Fentin-Hydroxide, Propiconazole, Pyraclostrobin Fungicides againstMicroorganisms · 2023Article
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- Status of Fungicide Resistance and Physiological Characterization of Tebuconazole Resistance inCurrent issues in molecular biology · 2022Article
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- Multiple Mutations and Overexpression in theCurrent issues in molecular biology · 2022Article
- Molecular characterization and overexpression of the difenoconazole resistance gene CYP51 in Lasiodiplodia theobromae field isolates.Scientific reports · 2021Article
- Characterization of the Molecular Mechanisms of Resistance against DMI Fungicides inJournal of fungi (Basel, Switzerland) · 2021Article
- Resistance to Boscalid, Fluopyram and Fluxapyroxad inMicroorganisms · 2021Article
- Molecular Mechanisms Underlying Fungicide Resistance in Citrus Postharvest Green Mold.Journal of fungi (Basel, Switzerland) · 2021Review
- Genome-Wide Association and Selective Sweep Studies Reveal the Complex Genetic Architecture of DMI Fungicide Resistance in Cercospora beticola.Genome biology and evolution · 2021Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Sterol demethylation inhibitor (DMI) fungicides are widely used to control fungi pathogenic to humans and plants. Resistance to DMIs is mediated either through alterations in the structure of the target enzyme CYP51 (encoding 14alpha-demethylase), through increased expression of the CYP51 gene, or through increased expression of efflux pumps. We found that CYP51 expression in DMI-resistant (DMI(R)) isolates of the cherry leaf spot pathogen Blumeriella jaapii was increased 5- to 12-fold compared to that in DMI-sensitive (DMI(S)) isolates. Analysis of sequences upstream of CYP51 in 59 DMI(R) isolates revealed that various forms of a truncated non-long terminal direct repeat long interspersed nuclear element retrotransposon were present in all instances. Similar inserts upstream of CYP51 were not present in any of 22 DMI(S) isolates examined.
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