ArticleJournal of clinical microbiology2006
Fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials.Lancet (London, England) · 2012Trial
- Use of acyclovir for suppression of human immunodeficiency virus infection is not associated with genotypic evidence of herpes simplex virus type 2 resistance to acyclovir: analysis of specimens from three phase III trials.Journal of clinical microbiology · 2010Trial
- Herpes Simplex Virus Hepatitis: An Overlooked Cause of Acute Liver Failure Across a Broad Spectrum of Immunocompromise.Liver international : official journal of the International Association for the Study of the Liver · 2026Review
- Severe acute herpes virus type 2 primo-infection and its association with anti-type 1 interferon autoantibodies.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Chemistry and anti-herpes simplex virus type 1 evaluation of 4-substituted-1H-1,2,3-triazole-nitroxyl-linked hybrids.Molecular diversity · 2021Article
- Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents.Molecules (Basel, Switzerland) · 2021Article
- Trillions and Trillions: Herpes Simplex Virus-1 Hepatitis in an Immunocompetent Adult.Open forum infectious diseases · 2019Article
- Review
- Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement.BMC infectious diseases · 2019Article
- Fatal encephalitis accompanied by ARDS in a child with HSV Infection.Pediatric investigation · 2018Article
- Fatal fulminant herpes simplex hepatitis following surgery in an adult.World journal of clinical cases · 2018Article
- Empirical treatment with parenteral acyclovir in a child with herpes simplex virus hepatitis and acute lymphoblastic leukemia.IDCases · 2018Article
- New strategies against drug resistance to herpes simplex virus.International journal of oral science · 2016Review
- Fulminant Hepatic Failure in a Patient with Crohn's Disease on Infliximab Possibly Related to Reactivation of Herpes Simplex Virus 2 Infection.Case reports in hepatology · 2016Article
- Mucosal herpes immunity and immunopathology to ocular and genital herpes simplex virus infections.Clinical & developmental immunology · 2012Review
- Quantification of viral DNA and liver enzymes in plasma improves early diagnosis and management of herpes simplex virus hepatitis.Journal of viral hepatitis · 2011Article
- Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management.Antimicrobial agents and chemotherapy · 2011Review
- Herpes Simplex Virus Hepatitis in an Immunocompetent Adult: A Fatal Outcome due to Liver Failure.Case reports in critical care · 2011Article
- Developing an asymptomatic mucosal herpes vaccine: the present and the future.Future microbiology · 2010Article
- Clinical correlates of herpes simplex virus viremia among hospitalized adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
We report an immunocompetent woman with multisystem organ failure following herpes simplex virus type 2 (HSV-2) hepatitis. After she initially responded to intravenous acyclovir, she was switched to oral valacyclovir. She developed respiratory failure and opportunistic infections and died. Autopsy confirmed disseminated HSV infection, and lung tissue grew acyclovir-resistant HSV-2.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.