ArticleJournal of clinical microbiology2006
Invasive Haemophilus influenzae in Manitoba, Canada, in the postvaccination era.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Invasive Haemophilus influenzae Infections after 3 Decades of Hib Protein Conjugate Vaccine Use.Clinical microbiology reviews · 2021Review
- Long Term Impact of Conjugate Vaccines onMicroorganisms · 2021Review
- Complete Genome Sequence of a Japanese Clinical Isolate of Haemophilus influenzae Type a Strain TAMBA230.Microbiology resource announcements · 2020Article
- InvasiveOpen forum infectious diseases · 2020Article
- Emergence of a clone of invasiveJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2020Article
- The emergingCanada communicable disease report = Releve des maladies transmissibles au Canada · 2017Article
- Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil.Memorias do Instituto Oswaldo Cruz · 2017Article
- Laboratory characterization of invasive Haemophilus influenzae isolates from Nunavut, Canada, 2000-2012.International journal of circumpolar health · 2016Article
- Adhesin genes and serum resistance in Haemophilus influenzae type f isolates.Journal of medical microbiology · 2013Article
- Epidemiology of vaccine-preventable invasive diseases in Catalonia in the era of conjugate vaccines.Human vaccines & immunotherapeutics · 2013Article
- Emergence of non-serotype b encapsulated Haemophilus influenzae as a cause of pediatric meningitis in northwestern Ontario.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2013Article
- The epidemiology of invasive disease due to Haemophilus influenzae serotype a in the Canadian North from 2000 to 2010.International journal of circumpolar health · 2013Article
- Haemophilus influenzae infections in the H. influenzae type b conjugate vaccine era.Journal of clinical microbiology · 2011Review
- Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion.The Journal of infectious diseases · 2010Article
- Genotypic characteristics of Haemophilus influenzae isolates from pediatric pneumonia patients in Chengdu city, Sichuan, China.Journal of microbiology (Seoul, Korea) · 2009Article
- Invasive bacterial diseases in northern Canada.Emerging infectious diseases · 2008Article
- Epidemiology of Haemophilus influenzae serotype a, North American Arctic, 2000-2005.Emerging infectious diseases · 2008Article
- Pulsed-field gel electrophoresis, pertactin, pertussis toxin S1 subunit polymorphisms, and surfaceome analysis of vaccine and clinical Bordetella pertussis strains.Clinical and vaccine immunology : CVI · 2007Article
- Virulence phenotypes of low-passage clinical isolates of nontypeable Haemophilus influenzae assessed using the chinchilla laniger model of otitis media.BMC microbiology · 2007Article
- Haemophilus influenzae type a infection and its prevention.Infection and immunity · 2007Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fifty-two Haemophilus influenzae isolates from patients with invasive disease in the province of Manitoba, Canada, were examined for serotype, biotype, genotype, and antibiotic susceptibility. Half of the 52 isolates were found to be serotype a, and 38.5% (20 isolates) were found to be nonserotypeable (NST). There were only three serotype b strains and one each for serotypes c, d, and f. All 26 serotype a isolates belonged to biotype II and demonstrated identical or highly similar DNA fingerprints by pulsed-field gel electrophoresis. An analysis of these isolates by multilocus sequence typing showed that they belong to the clonal complex ST-23. While 69% (18 of 26) of the serotype a cases were found in males, only 9 (45%) of the 20 patients with NST isolates were males. Twenty (77%) of the 26 serotype a isolates were from patients who were </=24 months old. Twelve (63%) of the NST isolates were from adult or adolescent patients. In contrast to the clonal nature of serotype a isolates, the 20 NST isolates were found to belong to 18 different sequence types. Most of these 18 different sequence types were unrelated to each other, with the exception of 7 sequence types grouped into three clonal groups. Two (6.25%) out of 32 serotypeable isolates (1 serotype a and 1 serotype b) and 6 (30%) of 20 NST isolates were resistant to ampicillin due to beta-lactamase production. These results suggest a change in the epidemiology of H. influenzae disease, with the majority of invasive H. influenzae isolates being associated with serotype a and NST strains.
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