ArticleProtein science : a publication of the Protein Society2006
The IclR family of transcriptional activators and repressors can be defined by a single profile.
Article in Protein science : a publication of the Protein Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Synthetic rhizosphere bacterial communities induce systemic resistance to barley powdery mildew without major shifts in the native bacterial community.Frontiers in microbiology · 2026Article
- RB-TnSeq elucidates dicarboxylic-acid-specific catabolism in β-proteobacteria for improved plastic monomer upcycling.Applied and environmental microbiology · 2025Article
- FucR Functions as a Transcriptional Regulator for L-Fucose Utilization inMicroorganisms · 2025Article
- Article
- A sweet new set of inducible and constitutive promoters inFrontiers in microbiology · 2023Article
- Article
- The structure and function of the global citrus rhizosphere microbiome.Nature communications · 2018Article
- Molecular control of gene expression byThe Journal of biological chemistry · 2018Article
- Crystal structure of an IclR homologue from Microbacterium sp. strain HM58-2.Acta crystallographica. Section F, Structural biology communications · 2017Article
- D101 is critical for the function of AttJ, a repressor of quorum quenching system in Agrobacterium tumefaciens.Journal of microbiology (Seoul, Korea) · 2015Article
- Functional Identification of OphR, an IclR Family Transcriptional Regulator Involved in the Regulation of the Phthalate Catabolic Operon in Rhodococcus sp. Strain DK17.Indian journal of microbiology · 2015Article
- Derepression of Mineral Phosphate Solubilization Phenotype by Insertional Inactivation of iclR in Klebsiella pneumoniae.PloS one · 2015Article
- In vivo analysis of DNA binding and ligand interaction of BlcR, an IclR-type repressor from Agrobacterium tumefaciens.Microbiology (Reading, England) · 2013Article
- Laboratory evolution of Geobacter sulfurreducens for enhanced growth on lactate via a single-base-pair substitution in a transcriptional regulator.The ISME journal · 2012Article
- KdgR, an IClR family transcriptional regulator, inhibits virulence mainly by repression of hrp genes in Xanthomonas oryzae pv. oryzae.Journal of bacteriology · 2011Article
- Intramolecular signal transmission in a tetrameric repressor of the IclR family.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The Agrobacterium tumefaciens transcription factor BlcR is regulated via oligomerization.The Journal of biological chemistry · 2011Article
- Effects of the putative transcriptional regulator IclR on Francisella tularensis pathogenesis.Infection and immunity · 2010Article
- Crystal structure of TtgV in complex with its DNA operator reveals a general model for cooperative DNA binding of tetrameric gene regulators.Genes & development · 2010Article
- TtgV represses two different promoters by recognizing different sequences.Journal of bacteriology · 2009Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In the last decade enormous advances in life sciences have been possible due to the information obtained from DNA sequencing projects. The optimal interpretation and analysis of genome sequence data requires the precise annotation and classification of proteins deduced from open reading frames, which is usually done with the help of family-specific signatures. Here we report a novel profile for the IclR type of transcriptional activators and repressors. In contrast to profiles for other families of transcriptional regulators, the new IclR profile is located outside the helix-turn-helix DNA-binding motif. We provide evidence that the new profile is more specific than any of the existing signatures for this family of regulators. More than 500 representatives of this family were identified with this profile. A database on bacterial regulators (http://www.bactregulators.org) was built to compile and regroup the sequences with the aid of the new profile.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.