ArticleGenome research2006
Alu-mediated 100-kb deletion in the primate genome: the loss of the agouti signaling protein gene in the lesser apes.
Article in Genome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- The howler monkey genome provides new insights into the distinctive howling and folivorous adaptations of New World monkeys.Genome biology · 2026Article
- A sequence of SVA retrotransposon insertions in ASIP shaped human pigmentation.Nature genetics · 2024Article
- Differential MC5R loss in whales and manatees reveals convergent evolution to the marine environment.Development genes and evolution · 2022Article
- Divergence and introgression in small apes, the genus Hylobates, revealed by reduced representation sequencing.Heredity · 2021Article
- Conceptual Evolution of Cell Signaling.International journal of molecular sciences · 2019Review
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- LINEs and SINEs of primate evolution.Evolutionary anthropology · 2010Article
- Evolutionary breakpoints in the gibbon suggest association between cytosine methylation and karyotype evolution.PLoS genetics · 2009Article
- The mysteries of chromosome evolution in gibbons: methylation is a prime suspect.PLoS genetics · 2009Article
- Article
- A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sheep.Genome research · 2008Article
- Investigation of the role of the agouti signaling protein gene (ASIP) in coat color evolution in primates.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Agouti signaling protein (ASIP) is an endogenous antagonist of melanocortin receptors that controls a wide range of physiological functions. Its central role in regulation of the melanocortin system implied that ASIP has been relevant to the evolution of various physiological traits in primates. In this study, we have tried to determine DNA sequences of the ASIP gene (ASIP) of various simian species to find molecular evolutionary aspects of ASIP. Unexpectedly, we found that the whole coding region of ASIP was missing only from the gibbon genome; gibbons constitute a large group of hominoid species in Southeast Asia. Our analyses revealed that unequal homologous recombination mediated by two AluSx elements erased a approximately 100-kb region including ASIP from the gibbon genome. The data provide new evidence for the significant roles of Alu elements in the dynamic evolution of the primate genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.