ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2006
Prenatal, perinatal, and heritable influences on cord blood immune responses.
Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed.
- Perinatal Bacterial Exposure Contributes to IL-13 Aeroallergen Response.American journal of respiratory cell and molecular biology · 2017Trial
- Relationship between the dietary inflammatory index and immune function during pregnancy - A secondary analysis of the MicrobeMom2 Study.European journal of clinical nutrition · 2026Article
- Prenatal blood metals, per- and polyfluoroalkyl substances and antigen- or mitogen-stimulated cord blood lymphocyte proliferation and cytokine secretion.Environmental research · 2024Article
- BORN TO WHEEZE OR LEARNED WHEN WE WERE YOUNG: MATERNAL AND ENVIRONMENTAL FACTORS INFLUENCE ATOPIC RISK.Transactions of the American Clinical and Climatological Association · 2023Article
- [Immune system and allergies-An unholy alliance].Der Internist · 2022Review
- Air Pollution, Neonatal Immune Responses, and Potential Joint Effects of Maternal Depression.International journal of environmental research and public health · 2021Article
- Prenatal Maternal Depression and Neonatal Immune Responses.Psychosomatic medicine · 2019Article
- Review
- It All Begins In Utero: Cord Blood Bacterial DNA and T Cell Immunity.American journal of respiratory cell and molecular biology · 2017Article
- "Cumulative Stress": The Effects of Maternal and Neonatal Oxidative Stress and Oxidative Stress-Inducible Genes on Programming of Atopy.Oxidative medicine and cellular longevity · 2016Review
- Genetics of transfusion recipient alloimmunization: can clues from susceptibility to autoimmunity pave the way?Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2014Review
- Epidemiology of stress and asthma: from constricting communities and fragile families to epigenetics.Immunology and allergy clinics of North America · 2011Review
- Exposure to moderate air pollution during late pregnancy and cord blood cytokine secretion in healthy neonates.PloS one · 2011Article
- Perinatal stress and early life programming of lung structure and function.Biological psychology · 2010Review
- Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses.The Journal of allergy and clinical immunology · 2009Article
- Innate immune mechanism in allergic asthma.Current allergy and asthma reports · 2008Review
- Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways.Human genetics · 2008Article
- Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression.Respiratory research · 2006Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundMaternal and perinatal environmental exposures, as well as inherited factors, may influence neonatal immune responses.
objectiveTo determine relations of maternal and perinatal exposures to antigen-specific cord blood lymphoproliferative responses.
methodsIn 427 newborns from a Boston pregnancy/birth cohort, lymphoproliferative responses in cord blood mononuclear cells to stimulation with cockroach (Bla g 2), house dust mite (Der f 1), ovalbumin, and mitogen phytohemagglutinin were measured as stimulation index (SI). We used the Wilcoxon rank sum and chi2 tests to evaluate predictors of ovalbumin SI as a continuous ranked or dichotomous outcome. We used t test and Spearman correlation for univariate testing and linear regression to evaluate predictors of natural log-transformed Bla g 2, Der f 1, and phytohemagglutinin SI. Logistic multivariate regression was applied to evaluate predictors of Bla g 2, Der f 1, and phytohemagglutinin SI dichotomized at 2 or at the median for phytohemagglutinin.
resultsMaternal smoking during pregnancy, inadequate or excessive maternal weight gain during pregnancy, neonate black race/ethnicity (compared with white), and Apgar score less than 8 were each independently associated with increased cord blood mononuclear cell proliferative responses to stimulation with Bla g 2 and/or Der f 1. Maternal history of asthma was associated only with increased lymphoproliferative response to ovalbumin stimulation.
conclusionsDistinct fetal and perinatal exposures and black race/ethnicity may be associated with increased cord blood lymphoproliferative responses. The implications of these findings for future development of allergy or asthma are, as yet, unknown.
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