ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Quantitative trait loci for baseline erythroid traits.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Review
- Strain-specific variations in cation content and transport in mouse erythrocytes.Physiological genomics · 2013Article
- QTLs for murine red blood cell parameters in LG/J and SM/J F(2) and advanced intercross lines.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Genetic analysis of hematological parameters in incipient lines of the collaborative cross.G3 (Bethesda, Md.) · 2012Article
- Article
- Molecular characterization and association analysis of porcine PANE1 gene.Molecular biology reports · 2010Article
- Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice.Physiological genomics · 2009Article
- An experimental assessment of in silico haplotype association mapping in laboratory mice.BMC genetics · 2009Article
- Quantitative trait loci for porcine baseline erythroid traits at three growth ages in a White Duroc x Erhualian F(2) resource population.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- QTL analyses of lineage-negative mouse bone marrow cells labeled with Sca-1 and c-Kit.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Quantitative trait loci for peripheral blood cell counts: a study in baboons.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A substantial genetic contribution underlies variation in baseline peripheral blood counts. We performed quantitative trait locus/loci (QTL) analyses to identify chromosome (Chr) regions harboring genes influencing the baseline erythroid parameters in F2 intercrosses between NZW/LacJ, SM/J, and C57BLKS/J inbred mice. We identified multiple significant QTL for red blood cell (RBC) count, hemoglobin (Hgb) and hematocrit (Hct) levels, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean cell hemoglobin concentration (CHCM). We identified four RBC count QTL: Rbcq1 (Chr 1, peak LOD score at 62 cM,), Rbcq2 (Chr 4, 60 cM), Rbcq3 (Chr 11, 34 cM), and Rbcq4 (Chr 10, 60 cM). Three MCV QTL were identified: Mcvq1 (Chr 7, 30 cM), Mvcq2 (Chr 11, 6 cM), and Mcvq3 (Chr 10, 60 cM). Single significant loci for Hgb (Hgbq1, Chr 16, 32 cM), Hct (Hctq1, Chr 3, 42 cM), and MCH (Mchq1, Chr 10, 60 cM) were identified. The data support the existence of a common RBC/MCH/MCV locus on Chr 10. Two QTL for CHCM (Chcmq1, Chr 2, 48 cM; Chcmq2, Chr 9, 44 cM) and an interaction between Chcmq2 with a locus on Chr 19 were identified. These analyses emphasize the genetic complexity underlying the regulation of erythroid peripheral blood traits in normal populations and suggest that genes not previously recognized as significantly impacting normal erythropoiesis exist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.