ArticleHistochemistry and cell biology2006
Perturbation of endothelial junction proteins by Staphylococcus aureus alpha-toxin: inhibition of endothelial gap formation by adrenomedullin.
Article in Histochemistry and cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
- A Secreted Glutamate-Specific Serine Protease fromPathogens (Basel, Switzerland) · 2026Article
- Multi-Omics Endotypes in ICU Sepsis-Induced Immunosuppression.Microorganisms · 2023Review
- CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells.Communications biology · 2021Article
- Mid-Regional Proadrenomedullin (MR-proADM) and Microcirculation in Monitoring Organ Dysfunction of Critical Care Patients With Infection: A Prospective Observational Pilot Study.Frontiers in medicine · 2021Article
- Adrenomedullin in Sepsis: Finally, a Friend or an Enemy?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections.Microorganisms · 2019Review
- Article
- Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study.Critical care (London, England) · 2018Observational
- Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure.Clinical science (London, England : 1979) · 2018Article
- The Role of Ubiquitination and Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate in the Degradation of the Adrenomedullin Type I Receptor.Scientific reports · 2017Article
- Lymphatic deletion of calcitonin receptor-like receptor exacerbates intestinal inflammation.JCI insight · 2017Article
- The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens.Pathogens (Basel, Switzerland) · 2016Review
- Therapeutic strategies in pneumonia: going beyond antibiotics.European respiratory review : an official journal of the European Respiratory Society · 2015Review
- Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome.Clinics in chest medicine · 2014Review
- Phenol-soluble modulins--critical determinants of staphylococcal virulence.FEMS microbiology reviews · 2014Review
- Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin.Critical care (London, England) · 2014Article
- Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives.Cell and tissue research · 2014Review
- Mechanisms of infective endocarditis: pathogen-host interaction and risk states.Nature reviews. Cardiology · 2014Review
- Cell-type-specific crosstalk between p38 MAPK and Rho signaling in lung micro- and macrovascular barrier dysfunction induced by Staphylococcus aureus-derived pathogens.Translational research : the journal of laboratory and clinical medicine · 2013Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endothelial hyperpermeability is a hallmark of an inflammatory reaction and contributes to tissue damage in severe infections. Loss of endothelial cell-cell adhesion leads to intercellular gap formation allowing paracellular fluid flux. Although Staphylococcus aureus alpha-toxin significantly contributed to staphylococci disease, little is known about its mechanism of endothelial hyperpermeability induction. Here, we demonstrate that in a model of isolated perfused rat ileum discontinuation of capillary vascular-endothelial-cadherin (VE-cadherin) was observed after bolus application of S. aureus alpha-toxin being inhibited by the endogenous peptide adrenomedullin (ADM). In vitro, alpha-toxin exposure induced loss of immunoreactivity of VE-cadherin and occludin in human cultured umbilical vein endothelial cells. Likewise, ADM blocked alpha-toxin-related junctional protein disappearance from intercellular sites. Additionally, cyclic AMP elevation was shown to stabilize endothelial barrier function after alpha-toxin application. Although no RhoA activation was noted after endothelial alpha-toxin exposure, inhibition of Rho kinase and myosin light chain kinase blocked loss of immunoreactivity of VE-cadherin and occludin as well as intercellular gap formation. In summary, stabilization of endothelial junctional integrity as indicated by interendothelial immunostaining might be an interesting approach to stabilize endothelial barrier function in severe S. aureus infections.
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