ReviewDiabetologia2006
Proinsulin in development: New roles for an ancient prohormone.
Review in Diabetologia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 71 citations in OpenAlex.
- Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish.Frontiers in nutrition · 2023Article
- Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa.Cell death & disease · 2022Article
- Duplication and diversification of insulin genes in ray-finned fish.Zoological research · 2019Article
- The Prohormone Proinsulin as a Neuroprotective Factor: Past History and Future Prospects.Frontiers in molecular neuroscience · 2018Review
- Proinsulin Promotes Self-Renewal of a Hematopoietic Progenitor Cell Line In Vitro.Journal of diabetes research · 2017Article
- Novel Aspects Concerning the Functional Cross-Talk between the Insulin/IGF-I System and Estrogen Signaling in Cancer Cells.Frontiers in endocrinology · 2015Review
- Non-neural tyrosine hydroxylase, via modulation of endocrine pancreatic precursors, is required for normal development of beta cells in the mouse pancreas.Diabetologia · 2014Article
- Evolution of the relaxin/insulin-like gene family in anthropoid primates.Genome biology and evolution · 2014Article
- Selected imprinting of INS in the marsupial.Epigenetics & chromatin · 2012Article
- Intestinal synthesis and secretion of bile salts as an adaptation to developmental biliary atresia in the sea lamprey.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The insulin and igf-I pathway in endocrine glands carcinogenesis.Journal of oncology · 2012Article
- Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish.General and comparative endocrinology · 2011Article
- Proinsulin: from hormonal precursor to neuroprotective factor.Frontiers in molecular neuroscience · 2011Article
- The regulated expression of chimeric tyrosine hydroxylase-insulin transcripts during early development.Nucleic acids research · 2006Article
- Taurine Increases Insulin Expression in STZ-Treated Rat Islet Cells In Vitro.Advances in experimental medicine and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In postnatal organisms, insulin is well known as an essential anabolic hormone responsible for maintaining glucose homeostasis. Its biosynthesis by the pancreatic beta cell has been considered a model of tissue-specific gene expression. However, proinsulin mRNA and protein have been found in embryonic stages before the formation of the pancreatic primordium, and later, in extrapancreatic tissues including the nervous system. Phylogenetic studies have also confirmed that production of insulin-like peptides antecedes the morphogenesis of a pancreas, and that these peptides contribute to normal development. In recent years, other roles for insulin distinct from its metabolic function have emerged also in vertebrates. During embryonic development, insulin acts as a survival factor and is involved in early morphogenesis. These findings are consistent with the observation that, at these stages, the proinsulin gene product remains as the precursor form, proinsulin. Independent of its low metabolic activity, proinsulin stimulates proliferation in developing neuroretina, as well as cell survival and cardiogenesis in early embryos. Insulin/proinsulin levels are finely regulated during development, since an excess of the protein interferes with correct morphogenesis and is deleterious for the embryo. This fine-tuned regulation is achieved by the expression of alternative embryonic proinsulin transcripts that have diminished translational activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.