ArticleProceedings of the National Academy of Sciences of the United States of America2006
The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 60 citations in OpenAlex.
- Article
- Review
- Intra- and Extracellular Effector Vesicles From Human T And NK Cells: Same-Same, but Different?Frontiers in immunology · 2021Review
- Sinner or Saint?: Nck Adaptor Proteins in Vascular Biology.Frontiers in cell and developmental biology · 2021Review
- Molecular mechanisms of FasL-mediated 'reverse-signaling'.Molecular immunology · 2020Review
- Genome-wide DNA methylation pattern in a mouse model reveals two novel genes associated with Staphylococcus aureus mastitis.Asian-Australasian journal of animal sciences · 2020Article
- Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion.Cancer medicine · 2019Article
- Impairment of Fas-ligand-caveolin-1 interaction inhibits Fas-ligand translocation to rafts and Fas-ligand-induced cell death.Cell death & disease · 2018Article
- The effector T cell response to influenza infection.Current topics in microbiology and immunology · 2015Review
- Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).PloS one · 2014Article
- From lipid second messengers to molecular motors: microtubule-organizing center reorientation in T cells.Immunological reviews · 2013Review
- Differential surface expression of ADAM10 and ADAM17 on human T lymphocytes and tumor cells.PloS one · 2013Article
- Essential role of the adaptor protein Nck1 in Jurkat T cell activation and function.Clinical and experimental immunology · 2012Article
- The regulated secretory pathway in CD4(+) T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapse.PLoS pathogens · 2011Article
- Effector granules in human T lymphocytes: the luminal proteome of secretory lysosomes from human T cells.Cell communication and signaling : CCS · 2011Article
- Cytotoxic immunological synapses.Immunological reviews · 2010Review
- Control of death receptor ligand activity by posttranslational modifications.Cellular and molecular life sciences : CMLS · 2010Review
- The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes.Protein science : a publication of the Protein Society · 2010Article
- Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.BMC immunology · 2009Article
- Enrichment and analysis of secretory lysosomes from lymphocyte populations.BMC immunology · 2009Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Fas ligand (FasL) is a key death factor of cytotoxic T lymphocytes and natural killer cells. It is stored intracellularly as a transmembrane protein of secretory lysosomes. Upon activation, these vesicles are transported to the cytotoxic immunological synapse (IS), and FasL becomes exposed to the cell surface to trigger cell death through ligation of its receptor Fas (CD95) on the target cell. We propose that the FasL-associated adaptor protein Nck is involved in the actin-dependent transport of FasL-bearing secretory lysosomes to the IS. Nck binds to the proline-rich portion of FasL and alters its subcellular distribution when coexpressed in 293T cells. In T lymphocytes, endogenous Nck partially colocalizes with lysosome-associated FasL. When T cell clones or lines are exposed to target cells, both proteins and other components of secretory lysosomes (i.e., granzyme B or cathepsin D) are transported to the cell-cell interface. The present data suggest that T cell receptor engagement provokes a rapid, tyrosine kinase- and actin-dependent transport of Nck-associated FasL-carrying lysosomes to the contact area. Our observations support the previous notion that the unique cytoplasmic tail of FasL is crucial for its directed transport to the cell surface and into the assembling cytotoxic IS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.