ArticleProceedings of the National Academy of Sciences of the United States of America2006
Rqh1 blocks recombination between sister chromatids during double strand break repair, independent of its helicase activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Homology-directed repair involves multiple strand invasion cycles in fission yeast.Molecular biology of the cell · 2022Article
- Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.PLoS genetics · 2014Article
- The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast.Nucleic acids research · 2014Article
- Fission yeast RecQ helicase Rqh1 is required for the maintenance of circular chromosomes.Molecular and cellular biology · 2013Article
- Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.Molecular and cellular biology · 2011Article
- Article
- Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast.The EMBO journal · 2009Article
- Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes.Molecular and cellular biology · 2009Article
- Article
- Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.PloS one · 2007Article
- Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.Molecular biology of the cell · 2007Article
- Mus81-Eme1-dependent and -independent crossovers form in mitotic cells during double-strand break repair in Schizosaccharomyces pombe.Molecular and cellular biology · 2007Article
- Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability.The Biochemical journal · 2006Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Many questions remain about the process of DNA double strand break (DSB) repair by homologous recombination (HR), particularly concerning the exact function played by individual proteins and the details of specific steps in this process. Some recent studies have shown that RecQ DNA helicases have a function in HR. We studied the role of the RecQ helicase Rqh1 with HR proteins in the repair of a DSB created at a unique site within the Schizosaccharomyces pombe genome. We found that DSBs in rqh1(+) cells, are predominantly repaired by interchromosomal gene conversion, with HR between sister chromatids [sister-chromatid conversion (SCC)], occurring less frequently. In Deltarqh1 cells, repair by SCC is favored, and gene conversion rates slow significantly. When we limited the potential for SCC in Deltarqh1 cells by reducing the length of the G2 phase of the cell cycle, DSB repair continued to be predominated by SCC, whereas it was essentially eliminated in wild-type cells. These data indicate that Rqh1 acts to regulate DSB repair by blocking SCC. Interestingly, we found that this role for Rqh1 is independent of its helicase activity. In the course of these studies, we also found nonhomologous end joining to be largely faithful in S. pombe, contrary to current belief. These findings provide insight into the regulation of DSB repair by RecQ helicases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.