ReviewThe AAPS journal2005
Mechanisms of drug-induced delayed-type hypersensitivity reactions in the skin.
Review in The AAPS journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 76 citations in OpenAlex.
- Case Report: Fluoxetine-induced leucocytoclastic vasculitis.Frontiers in psychiatry · 2026Article
- Review
- Bilateral tonic seizures probably induced by eperisone hydrochloride: a case report.Frontiers in neurology · 2023Article
- Why drug exposure is frequently associated with T-cell mediated cutaneous hypersensitivity reactions.Frontiers in toxicology · 2023Review
- Aspirin "Allergy"-Induced Thrombocytopenia: A Case Report.Journal of asthma and allergy · 2021Article
- Genomic Risk Factors Driving Immune-Mediated Delayed Drug Hypersensitivity Reactions.Frontiers in genetics · 2021Review
- Systemic Contact Dermatitis.Clinical reviews in allergy & immunology · 2019Review
- Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.Archives of toxicology · 2018Review
- Drug-Induced Skin Adverse Reactions: The Role of Pharmacogenomics in Their Prevention.Molecular diagnosis & therapy · 2018Review
- HIV-1 tat expression and sulphamethoxazole hydroxylamine mediated oxidative stress alter the disulfide proteome in Jurkat T cells.Virology journal · 2018Article
- Pharmacogenomics of off-target adverse drug reactions.British journal of clinical pharmacology · 2017Review
- Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor.Experimental dermatology · 2015Article
- Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models.Archives of toxicology · 2014Review
- ABCC2 Haplotype is Associated With Antituberculosis Drug-Induced Maculopapular Eruption.Allergy, asthma & immunology research · 2012Article
- Piperacillin/tazobactam induced thrombocytopaenia--a delayed response.BMJ case reports · 2012Article
- NAT2, CYP2C9, CYP2C19, and CYP2E1 genetic polymorphisms in anti-TB drug-induced maculopapular eruption.European journal of clinical pharmacology · 2011Article
- Sulfonamide allergy and cross-reactivity.Current allergy and asthma reports · 2007Review
- Drug hypersensitivity--where do we stand?The AAPS journal · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cutaneous drug reactions (CDRs) are the most commonly reported adverse drug reactions. These reactions can range from mildly discomforting to life threatening. CDRs can arise either from immunological or nonimmunological mechanisms, though the preponderance of evidence suggests an important role for immunological responses. Some cutaneous eruptions appear shortly after drug intake, while others are not manifested until 7 to 10 days after initiation of therapy and are consistent with delayed-type hypersensitivity. This review discusses critical steps in the initiation of delayed-type hypersensitivity reactions in the skin, which include protein haptenation, dendritic cell activation/migration and T-cell propagation. Recently, an alternative mechanism of drug presentation has been postulated that does not require bioactivation of the parent drug or antigen processing to elicit a drug-specific T-cell response. This review also discusses the role of various immune-mediators, such as cytokines, nitric oxide, and reactive oxygen species, in the development of delayed-type drug hypersensitivity reactions in skin. As keratinocytes have been shown to play a crucial role in the initiation and propagation of cutaneous immune responses, we also discuss the means by which these cells may initiate or modulate CDRs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.