ReviewHandbook of experimental pharmacology2006
Locked nucleic acid: high-affinity targeting of complementary RNA for RNomics.
Review in Handbook of experimental pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 84 citations in OpenAlex.
- Unveiling the intricacy of gapmer oligonucleotides through advanced tandem mass spectrometry approaches and scan accumulation for 2DMS.The Analyst · 2024Article
- Engineering circular RNA for molecular and metabolic reprogramming.Functional & integrative genomics · 2024Review
- Nanocarrier-Mediated Delivery of MicroRNAs for Fibrotic Diseases.Molecular diagnosis & therapy · 2024Review
- Expression ofMolecular therapy. Nucleic acids · 2023Article
- Review
- Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors.JCI insight · 2020Article
- Addressing Alzheimer's Disease (AD) Neuropathology Using Anti-microRNA (AM) Strategies.Molecular neurobiology · 2019Review
- Functional Roles of Sex-Biased, Growth Hormone-Regulated MicroRNAs miR-1948 and miR-802 in Young Adult Mouse Liver.Endocrinology · 2018Article
- Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells.Nature communications · 2017Article
- Managing Pancreatic Adenocarcinoma: A Special Focus in MicroRNA Gene Therapy.International journal of molecular sciences · 2016Review
- Manipulating miRNA Expression: A Novel Approach for Colon Cancer Prevention and Chemotherapy.Current pharmacology reports · 2015Article
- Article
- Tissue slide-based microRNA characterization of tumors: how detailed could diagnosis become for cancer medicine?Expert review of molecular diagnostics · 2014Review
- Article
- Article
- The non-coding road towards cardiac regeneration.Journal of cardiovascular translational research · 2013Review
- MicroRNAs as potential clinical biomarkers: emerging approaches for their detection.Biotechnic & histochemistry : official publication of the Biological Stain Commission · 2013Article
- miR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling.Oncogene · 2013Article
- Long-range architecture in a viral RNA genome.Biochemistry · 2013Article
- MicroRNAs in common human diseases.Genomics, proteomics & bioinformatics · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Locked nucleic acid (LNA) is a nucleic acid analog containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA-mimicking sugar conformation. This conformational restriction is translated into unprecedented hybridization affinity towards complementary single-stranded RNA molecules. That makes fully modified LNAs, LNA/DNA mixmers, or LNA/RNA mixmers uniquely suited for mimicking RNA structures and for RNA targeting in vitro or in vivo. The focus of this chapter is on LNA antisense, LNA-modified DNAzymes (LNAzymes), LNA-modified small interfering (si)RNA (siLNA), LNA-enhanced expression profiling by real-time RT-PCR and detection and analysis of microRNAs by LNA-modified probes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.