ReviewHandbook of experimental pharmacology2006
RNA interference: its use as antiviral therapy.
Review in Handbook of experimental pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Perspectives on the Use of Small Noncoding RNAs as a Therapy for Severe Virus-Induced Disease Manifestations and Late Complications.BioNanoScience · 2022Review
- Multiple dengue virus serotypes resistant transgenicRNA biology · 2020Article
- Review
- DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs.Molecular therapy. Nucleic acids · 2018Article
- cfa-miR-143 Promotes Apoptosis via the p53 Pathway in Canine Influenza Virus H3N2-Infected Cells.Viruses · 2017Article
- Antivirals against animal viruses.Biochemical pharmacology · 2017Review
- Short Interfering RNA Inhibits Rift Valley Fever Virus Replication and Degradation of Protein Kinase R in Human Cells.Frontiers in microbiology · 2016Article
- The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities.Nucleic acids research · 2015Review
- RNAi: antiviral therapy against dengue virus.Asian Pacific journal of tropical biomedicine · 2013Review
- A new short oligonucleotide-based strategy for the precursor-specific regulation of microRNA processing by dicer.PloS one · 2013Article
- Inhibition of Tulane virus replication in vitro with RNA interference.Journal of medical virology · 2013Article
- In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important.Nucleic acids research · 2012Article
- RNA interference against animal viruses: how morbilliviruses generate extended diversity to escape small interfering RNA control.Journal of virology · 2012Article
- Computational approaches to 3D modeling of RNA.Journal of physics. Condensed matter : an Institute of Physics journal · 2010Review
- Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies.RNA (New York, N.Y.) · 2010Article
- RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequences.Nucleic acids research · 2009Article
- Toward a durable anti-HIV gene therapy based on RNA interference.Annals of the New York Academy of Sciences · 2009Review
- Antiviral strategies.Handbook of experimental pharmacology · 2009Review
- Two approaches to construct mammalian expression vector of shRNA to reduce expression and replication of HBV in vitro.Molecular biology reports · 2008Article
- Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron.Nucleic acids research · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA interference (RNAi) is a sequence-specific gene-silencing mechanism that has been proposed to function as a defence mechanism of eukaryotic cells against viruses and transposons. RNAi was first observed in plants in the form of a mysterious immune response to viral pathogens. But RNAi is more than just a response to exogenous genetic material. Small RNAs termed microRNA (miRNA) regulate cellular gene expression programs to control diverse steps in cell development and physiology. The discovery that exogenously delivered short interfering RNA (siRNA) can trigger RNAi in mammalian cells has made it into a powerful technique for generating genetic knock-outs. It also raises the possibility to use RNAi technology as a therapeutic tool against pathogenic viruses. Indeed, inhibition of virus replication has been reported for several human pathogens including human immunodeficiency virus, the hepatitis B and C viruses and influenza virus. We reviewed the field of antiviral RNAi research in 2003 (Haasnoot et al. 2003), but many new studies have recently been published. In this review, we present a complete listing of all antiviral strategies published up to and including December 2004. The latest developments in the RNAi field and their antiviral application are described.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.