ArticleMedical & biological engineering & computing2005
Modelling passive cardiac conductivity during ischaemia.
Article in Medical & biological engineering & computing, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Accurate diagnosis of severe coronary stenosis based on resting magnetocardiography: a prospective, single-center, cross-sectional analysis.Journal of geriatric cardiology : JGC · 2024Article
- Confocal microscopy-based estimation of intracellular conductivities in myocardium for modeling of the normal and infarcted heart.Computers in biology and medicine · 2022Article
- Uncertainty Quantification in Simulations of Myocardial Ischemia.Computing in cardiology · 2021Article
- Deriving the Bidomain Model of Cardiac Electrophysiology From a Cell-Based Model; Properties and Comparisons.Frontiers in physiology · 2021Article
- Effectiveness of magnetocardiography to identify patients in need of coronary artery revascularization: a cross-sectional study.Cardiovascular diagnosis and therapy · 2020Article
- Quantifying the effect of uncertainty in input parameters in a simplified bidomain model of partial thickness ischaemia.Medical & biological engineering & computing · 2018Article
- Cardiac ischemia-insights from computational models.Herzschrittmachertherapie & Elektrophysiologie · 2018Review
- Engineering Biodegradable and Biocompatible Bio-ionic Liquid Conjugated Hydrogels with Tunable Conductivity and Mechanical Properties.Scientific reports · 2017Article
- Repolarization Heterogeneity of Magnetocardiography Predicts Long-Term Prognosis in Patients with Acute Myocardial Infarction.Yonsei medical journal · 2016Article
- The role of blood vessels in high-resolution volume conductor head modeling of EEG.NeuroImage · 2016Article
- Inverse Electrocardiographic Source Localization of Ischemia: An Optimization Framework and Finite Element Solution.Journal of computational physics · 2013Article
- Influence of ischemic core muscle fibers on surface depolarization potentials in superfused cardiac tissue preparations: a simulation study.Medical & biological engineering & computing · 2012Article
- Incorporating histology into a 3D microscopic computer model of myocardium to study propagation at a cellular level.Annals of biomedical engineering · 2010Article
- Subject-specific, multiscale simulation of electrophysiology: a software pipeline for image-based models and application examples.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2009Article
- A Model of 3D Propagation in Discrete Cardiac Tissue.Computers in cardiology · 2006Article
- Image-based modeling of acute myocardial ischemia using experimentally derived ischemic zone source representations.Journal of electrocardiologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The results of a geometric model of cardiac tissue, used to compute the bidomain conductivity tensors during three phases of ischaemia, are described. Ischaemic conditions were simulated by model parameters being changed to match the morphological and electrical changes of three phases of ischaemia reported in literature. The simulated changes included collapse of the interstitial space, cell swelling and the closure of gap junctions. The model contained 64 myocytes described by 2 million tetrahedral elements, to which an external electric field was applied, and then the finite element method was used to compute the associated current density. In the first case, a reduction in the amount of interstitial space led to a reduction in extracellular longitudinal conductivity by about 20%, which is in the range of reported literature values. Moderate cell swelling in the order of 10-20% did not affect extracellular conductivity considerably. To match the reported drop in total tissue conductance reported in experimental studies during the third phase of ischaemia, a ten fold increase in the gap junction resistance was simulated. This ten-fold increase correlates well with the reported changes in gap junction densities in the literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.