ArticleProceedings of the National Academy of Sciences of the United States of America1987
G protein and diacylglycerol regulate metamorphosis of planktonic molluscan larvae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 81 citations in OpenAlex.
- Metamorphosis of the purple sea urchin Heliocidaris crassispina: Single-cell transcriptomic datasets.Scientific data · 2026Article
- Molluscan Genomes Reveal Extensive Differences in Photopigment Evolution Across the Phylum.Molecular biology and evolution · 2023Article
- Genetic independence between traits separated by metamorphosis is widespread but varies with biological function.Proceedings. Biological sciences · 2023Article
- Symbiotic microbiome and metabolism profiles reveal the effects of induction by oysters on the metamorphosis of the carnivorous gastropodComputational and structural biotechnology journal · 2022Article
- Proteomic analysis of trochophore and veliger larvae development in the small abalone Haliotis diversicolor.BMC genomics · 2017Article
- An ancient role for nitric oxide in regulating the animal pelagobenthic life cycle: evidence from a marine sponge.Scientific reports · 2016Article
- Developmental Transcriptome Analysis and Identification of Genes Involved in Larval Metamorphosis of the Razor Clam, Sinonovacula constricta.Marine biotechnology (New York, N.Y.) · 2016Article
- SARP19 and vdg3 gene families are functionally related during abalone metamorphosis.Development genes and evolution · 2014Article
- Mechanisms underlying dual effects of serotonin during development of Helisoma trivolvis (Mollusca).BMC developmental biology · 2014Article
- Nitric oxide acts as a positive regulator to induce metamorphosis of the ascidian Herdmania momus.PloS one · 2013Article
- Article
- Chemically induced metamorphosis of polychaete larvae in both the laboratory and ocean environment.Journal of chemical ecology · 1990Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regulatory guanine nucleotide binding protein (G protein) activators cholera toxin and the GTP analog 5-guanylyl imidophosphate, the second messenger diacylglycerol, and certain diamino acids all facilitate (amplify) the settlement and metamorphic responses of planktonic larvae of Haliotis rufescens (marine mollusc) to morphogenetic chemical stimuli. In contrast, the G protein-inhibiting analog guanosine 5'-O-[beta-thio]diphosphate inhibits facilitation by L-alpha,beta-diaminopropionic acid but does not block facilitation by diacylglycerol. Diacylglycerol, cholera toxin, and the guanine nucleotide analogs alone neither induce the settlement and metamorphosis of the larvae nor do they inhibit induction of metamorphosis by gamma-aminobutyric acid. These results thus establish the existence of separate regulatory and inductive pathways controlling larval metamorphosis in response to two classes of exogenous chemical signals from the environment. The regulatory pathway, operating independently through a G protein-diacylglycerol cascade apparently controlled by facilitating diamino acids in the water column, can amplify the larval responsiveness to inducers of metamorphosis. This mechanism may have adaptive significance in the recognition and selection of favorable habitats for metamorphosis of the larvae. Similar regulatory pathways, based on exogenous control of a G protein-diacylglycerol cascade, may govern responsiveness to stimuli in other sensory and developmental systems.
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Registered trials
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