ArticleThe Journal of infectious diseases2006
Evaluating the impact of hepatitis C virus (HCV) on highly active antiretroviral therapy-mediated immune responses in HCV/HIV-coinfected women: role of HCV on expression of primed/memory T cells.
Article in The Journal of infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 46 citations in OpenAlex.
- Human Immunodeficiency Virus Is Associated With Elevated FibroScan-Aspartate Aminotransferase (FAST) Score.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Multisite prospective Liver Disease and Reproductive Ageing (LIVRA) study in US women living with and without HIV.BMJ open · 2022Article
- Observational
- Frequent Occurrence of Pain and Prescription Opioid Use for Treatment of Pain Among Women with and at Risk for HIV Infection.AIDS and behavior · 2018Article
- Association of a 3' untranslated region polymorphism in proprotein convertase subtilisin/kexin type 9 with HIV viral load and CD4+ levels in HIV/hepatitis C virus coinfected women.AIDS (London, England) · 2017Article
- HCV coinfection contributes to HIV pathogenesis by increasing immune exhaustion in CD8 T-cells.PloS one · 2017Article
- Association of Hepatitis C Virus Infection With CD4/CD8 Ratio in HIV-Positive Women.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Systemic Immune Activation and HIV Shedding in the Female Genital Tract.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Relationship between Body Mass Index and Mortality in HIV-Infected HAART Users in the Women's Interagency HIV Study.PloS one · 2015Article
- The Novel Cyclophilin Inhibitor CPI-431-32 Concurrently Blocks HCV and HIV-1 Infections via a Similar Mechanism of Action.PloS one · 2015Article
- T-cell activation, both pre- and post-HAART levels, correlates with carotid artery stiffness over 6.5 years among HIV-infected women in the WIHS.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Association of chronic hepatitis C infection with T-cell phenotypes in HIV-negative and HIV-positive women.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Alteration of select gene expression patterns in individuals infected with HIV-1.Journal of medical virology · 2014Article
- Association of self-reported race with AIDS death in continuous HAART users in a cohort of HIV-infected women in the United States.AIDS (London, England) · 2013Article
- Hepatitis C Virus and HIV Type 1 Co-Infection.Infectious disease reports · 2013Review
- Association of HIV clinical disease progression with profiles of early immune activation: results from a cluster analysis approach.AIDS (London, England) · 2013Article
- Association of hepatitis C with markers of hemostasis in HIV-infected and uninfected women in the women's interagency HIV study (WIHS).Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Hepatitis C viremia is associated with cytomegalovirus IgG antibody levels in HIV-infected women.PloS one · 2013Article
- Complementary role of HCV and HIV in T-cell activation and exhaustion in HIV/HCV coinfection.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the impact of hepatitis C virus (HCV) on the immune system before receipt of highly active antiretroviral therapy (HAART) and on immune recovery after receipt of HAART among human immunodeficiency virus (HIV)/HCV-coinfected women enrolled in the Women's Interagency HIV Study.
methodsThe study included 294 HIV-infected women who initiated HAART and attended 2 follow-up visits. The women were grouped on the basis of positive HCV antibody and HCV RNA tests. There were 148 women who were HCV antibody negative, 34 who were HCV antibody positive but RNA negative, and 112 who were HCV antibody and RNA positive. Immune recovery was measured by flow-cytometric assessment for markers of activation and maturation on CD4+ and CD8+ T cells. Data analysis used repeated measures of variance.Results. HIV/HCV coinfection is associated with an increased number of CD4+ and CD8+ primed/memory T cells. HIV/HCV coinfection, however, did not affect any further decreases in CD4+ or CD4+ and CD8+ naive/memory T cell counts or enhanced T cell activation. HIV/HCV coinfection also did not affect HAART responses in the CD4+ and CD8+ T cell compartment.
conclusionsHCV does not affect immune responses to HAART in HIV/HCV-coinfected individuals but is associated with an expansion of CD4+ and CD8+ memory T cell subsets. Functional impairment in the CD4+ and CD8+ T cell compartments still needs to be assessed in coinfected patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.