ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2006
Early diagnosis of SARS: lessons from the Toronto SARS outbreak.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Surviving SARS and living through COVID-19: Healthcare worker mental health outcomes and insights for coping.PloS one · 2021Trial
- The presence of psychological distress in healthcare workers across different care settings in Windsor, Ontario, during the COVID-19 pandemic: A cross-sectional study.Frontiers in psychology · 2022Article
- Clinical diagnosis of severe COVID-19: A derivation and validation of a prediction rule.World journal of clinical cases · 2021Article
- Article
- Clinical Symptoms and Types of Samples Are Critical Factors for the Molecular Diagnosis of Symptomatic COVID-19 Patients: A Systematic Literature Review.International journal of microbiology · 2021Review
- Perspective on the Role of Antibodies and Potential Therapeutic Drugs to Combat COVID-19.The protein journal · 2020Review
- Community Health Workers and Pandemic Preparedness: Current and Prospective Roles.Frontiers in public health · 2019Article
- A "Syndromic" Approach for Diagnosing and Managing Travel-Related Infectious Diseases in Children.Current problems in pediatric and adolescent health care · 2015Review
- A North/South collaboration between two national public health institutes--a model for global health protection.Journal of public health policy · 2015Article
- Genetic associations of fatigue and other symptom domains of the acute sickness response to infection.Brain, behavior, and immunity · 2012Article
- Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study.BMC neurology · 2011Article
- Effectiveness of ribavirin and corticosteroids for severe acute respiratory syndrome.The American journal of medicine · 2009Article
- Establishing a surveillance network for severe lower respiratory tract infections in Korean infants and young children.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Human immunopathogenesis of severe acute respiratory syndrome (SARS).Virus research · 2008Article
- Impact on health care workers employed in high-risk areas during the Toronto SARS outbreak.Journal of psychosomatic research · 2008Article
- Adverse events associated with high-dose ribavirin: evidence from the Toronto outbreak of severe acute respiratory syndrome.Pharmacotherapy · 2007Article
- Role of laboratory variables in differentiating SARS-coronavirus from other causes of community-acquired pneumonia within the first 72 h of hospitalization.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2006Article
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical presentation of SARS is nonspecific and diagnostic tests do not provide accurate results early in the disease course. Initial diagnosis remains reliant on clinical assessment. To identify features of the clinical assessment that are useful in SARS diagnosis, the exposure status and the prevalence and timing of symptoms, signs, laboratory and radiographic findings were determined for all adult patients admitted with suspected SARS during the Toronto SARS outbreak. Findings were compared between patients with laboratory-confirmed SARS and those in whom SARS was excluded by laboratory or public health investigation. Of 364 cases, 273 (75%) had confirmed SARS, 30 (8%) were excluded, and 61 (17%) remained indeterminate. Among confirmed cases, exposure occurred in the healthcare environment (80%) or in the households of affected patients (17%); community or travel-related cases were rare (<3%). Fever occurred in 97% of patients by the time of admission. Respiratory findings including cough, dyspnea and pulmonary infiltrates evolved later and were present in only 59, 37 and 68% of patients, respectively, at admission. Direct exposure, fever on the first day of illness, and elevated temperature, pulmonary infiltrates, lymphopenia and thrombocytopenia at admission were associated with confirmed cases. Rhinorrhea, sore throat, and an elevated neutrophil count at admission were associated with excluded cases. In the absence of fever or significant exposure, SARS is unlikely. Other clinical, laboratory and radiographic findings further raise or lower the likelihood of SARS and provide a rational basis for estimating the likelihood of SARS and directing initial management.
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