ReviewThe Journal of clinical investigation2006
Harnessing preclinical mouse models to inform human clinical cancer trials.
Review in The Journal of clinical investigation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- An Overview of Optic Pathway Glioma With Neurofibromatosis Type 1: Pathogenesis, Risk Factors, and Therapeutic Strategies.Investigative ophthalmology & visual science · 2024Review
- Studying intramuscular fat deposition and muscle regeneration: insights from a comparative analysis of mouse strains, injury models, and sex differences.Skeletal muscle · 2024Article
- Article
- Current status of MEK inhibitors in the treatment of plexiform neurofibromas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development.Nature communications · 2020Article
- Comparative study of preclinical mouse models of high-grade glioma for nanomedicine research: the importance of reproducing blood-brain barrier heterogeneity.Theranostics · 2020Article
- Cancer drug development: The missing links.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Novel technique for high-precision stereotactic irradiation of mouse brains.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2016Article
- Early phase clinical trials to identify optimal dosing and safety.Molecular oncology · 2015Review
- Co-clinical trials demonstrate superiority of crizotinib to chemotherapy in ALK-rearranged non-small cell lung cancer and predict strategies to overcome resistance.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- MR imaging features of high-grade gliomas in murine models: how they compare with human disease, reflect tumor biology, and play a role in preclinical trials.AJNR. American journal of neuroradiology · 2012Review
- Article
- Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo.Neuro-oncology · 2010Article
- MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent Mechanisms.Genes & cancer · 2010Article
- Genetically engineered mouse models in cancer research.Advances in cancer research · 2010Review
- Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma.International journal of radiation oncology, biology, physics · 2009Article
- Current status of sporadic and neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.Current oncology reports · 2009Review
- Using neurofibromatosis-1 to better understand and treat pediatric low-grade glioma.Journal of child neurology · 2008Review
- Fatigue and sleep during cancer and chemotherapy: translational rodent models.Comparative medicine · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The urgent need for better cancer treatments has stimulated interest in employing small-animal models to evaluate potential drug therapies. Robust mouse models of many human cancers have been generated using sophisticated technologies for engineering germ-line mutations. As we enter into an age of targeted therapeutics, these strains provide novel platforms for validating new anticancer drugs, assessing therapeutic index, identifying surrogate markers of tumor progression, and defining epigenetic and environmental influences on tumorigenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.