ArticleJournal of bacteriology2006
DNA microarray and proteomic analyses of the RpoS regulon in Geobacter sulfurreducens.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Environmental considerations and bioremediation applications of the metal-, nitrate-, and organohalide-respiring bacteriumApplied and environmental microbiology · 2026Review
- Comparative insights into genome signatures of ferric iron oxide- and anode-stimulated Desulfuromonas spp. strains.BMC genomics · 2021Article
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- Development of Teleost Intermuscular Bones Undergoing Intramembranous Ossification Based on Histological-Transcriptomic-Proteomic Data.International journal of molecular sciences · 2019Article
- Expression of Genes and Proteins Involved in Arsenic Respiration and Resistance in Dissimilatory Arsenate-ReducingApplied and environmental microbiology · 2019Article
- Combined Transcriptome and Proteome Analysis of RpoS Regulon Reveals Its Role in Spoilage Potential ofFrontiers in microbiology · 2019Article
- Comparative metabolomic studies of Alkanivorax xenomutans showing differential power output in a three chambered microbial fuel cell.World journal of microbiology & biotechnology · 2017Article
- Proteome remodelling by the stress sigma factor RpoS/σScientific reports · 2017Article
- Abundance of the multiheme c-type cytochrome OmcB increases in outer biofilm layers of electrode-grown Geobacter sulfurreducens.PloS one · 2014Article
- Article
- The RpoS Sigma Factor Negatively Regulates Production of IAA and Siderophore in a Biocontrol Rhizobacterium, Pseudomonas chlororaphis O6.The plant pathology journal · 2013Article
- Genomic determinants of organohalide-respiration in Geobacter lovleyi, an unusual member of the Geobacteraceae.BMC genomics · 2012Article
- Phylogenetic classification of diverse LysR-type transcriptional regulators of a model prokaryote Geobacter sulfurreducens.Journal of molecular evolution · 2012Article
- Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury.The Journal of clinical investigation · 2012Article
- Genomic and proteomic analysis of the impact of mitotic quiescence on the engraftment of human CD34+ cells.PloS one · 2011Article
- Characterization of proton production and consumption associated with microbial metabolism.BMC biotechnology · 2010Article
- Genome-wide analysis of the RpoN regulon in Geobacter sulfurreducens.BMC genomics · 2009Article
- Article
- Diversity of promoter elements in a Geobacter sulfurreducens mutant adapted to disruption in electron transfer.Functional & integrative genomics · 2009Review
- Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle.Molecular microbiology · 2007Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regulon of the sigma factor RpoS was defined in Geobacter sulfurreducens by using a combination of DNA microarray expression profiles and proteomics. An rpoS mutant was examined under steady-state conditions with acetate as an electron donor and fumarate as an electron acceptor and with additional transcriptional profiling using Fe(III) as an electron acceptor. Expression analysis revealed that RpoS acts as both a positive and negative regulator. Many of the RpoS-dependent genes determined play roles in energy metabolism, including the tricarboxylic acid cycle, signal transduction, transport, protein synthesis and degradation, and amino acid metabolism and transport. As expected, RpoS activated genes involved in oxidative stress resistance and adaptation to nutrient limitation. Transcription of the cytochrome c oxidase operon, necessary for G. sulfurreducens growth using oxygen as an electron acceptor, and expression of at least 13 c-type cytochromes, including one previously shown to participate in Fe(III) reduction (MacA), were RpoS dependent. Analysis of a subset of the rpoS mutant proteome indicated that 15 major protein species showed reproducible differences in abundance relative to those of the wild-type strain. Protein identification using mass spectrometry indicated that the expression of seven of these proteins correlated with the microarray data. Collectively, these results indicate that RpoS exerts global effects on G. sulfurreducens physiology and that RpoS is vital to G. sulfurreducens survival under conditions typically encountered in its native subsurface environments.
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