ArticleProceedings of the National Academy of Sciences of the United States of America2006
High expression of a cytokeratin-associated protein in many cancers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Tuning the gate and the gear: The LRRC26 (γ1) subunit modulates intrinsic gating and voltage-sensor coupling of the BK channel.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tuning the gate and the gear: The LRRC26 (bioRxiv : the preprint server for biology · 2025Article
- The LRRC family of BK channel regulatory subunits: potential roles in health and disease.The Journal of physiology · 2022Review
- BK Channel in the Physiology and in the Cancer of Pancreatic Duct: Impact and Reliability of BK Openers.Frontiers in pharmacology · 2022Review
- Roles of LRRC26 as an auxiliary γ1-subunit of large-conductance CaAmerican journal of physiology. Lung cellular and molecular physiology · 2020Article
- Emerging roles for multifunctional ion channel auxiliary subunits in cancer.Cell calcium · 2019Review
- Longitudinal autoantibody responses against tumor-associated antigens decrease in breast cancer patients according to treatment modality.BMC cancer · 2018Article
- Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Clinical biocharacterization of immunophenotype in hepatocellular carcinoma patients.International journal of clinical and experimental pathology · 2017Article
- Targeted sequencing in chromosome 17q linkage region identifies familial glioma candidates in the Gliogene Consortium.Scientific reports · 2015Article
- Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis.Molecular cancer research : MCR · 2013Article
- The human cell surfaceome of breast tumors.BioMed research international · 2013Article
- BK potassium channel modulation by leucine-rich repeat-containing proteins.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis.Oncogene · 2012Article
- The LRRC26 protein selectively alters the efficacy of BK channel activators.Molecular pharmacology · 2012Article
- LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium.Nature · 2010Article
- Non-AUG translational initiation of a short CAPC transcript generating protein isoform.Biochemical and biophysical research communications · 2009Article
- Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Intermediate filaments: a role in epithelial polarity.Experimental cell research · 2007Review
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11 authors.
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Abstract
We have described previously a cDNA library made from membrane-bound polysomal mRNA prepared from breast and prostate cancer cell lines. The library is highly enriched for cDNAs encoding membrane proteins, secreted proteins, and cytokeratins. To characterize this library, 25,277 cDNA clones were sequenced and aligned with various databases; 1,439 clones did not align with known genes. From this set of clones we identified a previously uncharacterized gene encoding a 334-aa protein. Although protein structural motif prediction programs indicate that the gene encodes a membrane protein comprising a signal sequence, a series of leucine-rich repeats, and a single transmembrane domain with a cytoplasmic tail, confocal microscopy of MCF7 breast cancer cells demonstrates that the protein is not directly associated with the plasma membrane or intracellular membranes but instead colocalizes with intermediate filaments and cytokeratins within the cell. Immunofluorescence studies also show that protein expression is increased greatly in mitotic MCF7 cells, and immunohistochemistry demonstrates its expression in human breast cancer cells. Analysis of mRNA levels in 25 different normal tissues by RT-PCR shows that this gene is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. RT-PCR studies on human cancer samples show that the RNA is expressed highly in many cancer cell lines and cancer specimens, including 26 of 33 human breast cancers, 3 of 3 prostate cancers, 3 of 3 colon cancers, and 3 of 3 pancreatic cancers. We name the protein CAPC, cytokeratin-associated protein in cancer.
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