ArticleProceedings of the National Academy of Sciences of the United States of America2006
The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 158 citations in OpenAlex.
- Epigenetically regulated transcriptional repressor, BASIC PENTACYSTEINE1 (BPC1) acts together with polycomb repressive complex 2 (PRC2) to suppress camalexin biosynthesis in Arabidopsis.Plant molecular biology · 2026Article
- The oily nucleus- role of phospholipids in genome biology: membrane-directed roles and signaling in the nucleoplasm.Cellular and molecular life sciences : CMLS · 2025Review
- Exploring lipid-protein interactions in plant membranes.Journal of experimental botany · 2024Review
- When PIPFrontiers in cell and developmental biology · 2022Review
- Ectopic Overexpression of Histone H3K4 Methyltransferase CsSDG36 from Tea Plant Decreases Hyperosmotic Stress Tolerance inInternational journal of molecular sciences · 2021Article
- The function of histone lysine methylation related SET domain group proteins in plants.Protein science : a publication of the Protein Society · 2020Review
- The Trithorax Group Factor ULTRAPETALA1 Regulates Developmental as Well as Biotic and Abiotic Stress Response Genes in Arabidopsis.G3 (Bethesda, Md.) · 2019Article
- Review
- Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage.International journal of molecular sciences · 2019Review
- The Histone Demethylase IBM1 Positively RegulatesFrontiers in plant science · 2019Article
- Phospholipids and inositol phosphates linked to the epigenome.Histochemistry and cell biology · 2018Review
- SIP1 participates in regulation of flowering time in rice by recruiting OsTrx1 to Ehd1.The New phytologist · 2018Article
- The function of OsbHLH068 is partially redundant with its homolog, AtbHLH112, in the regulation of the salt stress response but has opposite functions to control flowering in Arabidopsis.Plant molecular biology · 2017Article
- GEM, a member of the GRAM domain family of proteins, is part of the ABA signaling pathway.Scientific reports · 2016Article
- Role of Arabidopsis AtPI4Kγ3, a type II phosphoinositide 4-kinase, in abiotic stress responses and floral transition.Plant biotechnology journal · 2016Article
- JMJ704 positively regulates rice defense response against Xanthomonas oryzae pv. oryzae infection via reducing H3K4me2/3 associated with negative disease resistance regulators.BMC plant biology · 2015Article
- Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.Molecular & cellular proteomics : MCP · 2015Article
- The Phaseolus vulgaris PvTRX1h gene regulates plant hormone biosynthesis in embryogenic callus from common bean.Frontiers in plant science · 2015Article
- Chromatin versus pathogens: the function of epigenetics in plant immunity.Frontiers in plant science · 2015Review
- Exploring phosphatidylinositol 5-phosphate 4-kinase function.Advances in biological regulation · 2015Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Arabidopsis homolog of trithorax, ATX1, regulates numerous functions in Arabidopsis beyond the homeotic genes. Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. PI5P negatively affects ATX1 activity, suggesting a regulatory pathway connecting lipid-signaling with nuclear functions. We propose a model to illustrate how plants may respond to stimuli (external or internal) that elevate cellular PI5P levels by altering expression of ATX1-controlled genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.