ArticleThe Journal of cell biology2006
Mcp5, a meiotic cell cortex protein, is required for nuclear movement mediated by dynein and microtubules in fission yeast.
Article in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.PLoS biology · 2024Article
- Ninein promotes F-actin cup formation and inward phagosome movement during phagocytosis in macrophages.Molecular biology of the cell · 2024Article
- A force balance model for a cell size-dependent meiotic nuclear oscillation in fission yeast.EMBO reports · 2023Article
- Stochastic model of T cell repolarization during target elimination (II).Biophysical journal · 2022Article
- Hierarchical integration of mitochondrial and nuclear positioning pathways by the Num1 EF hand.Molecular biology of the cell · 2022Article
- Spatiotemporal Dynamic Regulation of Organelles During Meiotic Development, Insights From Fungi.Frontiers in cell and developmental biology · 2022Article
- Overexpression of Mdm36 reveals Num1 foci that mediate dynein-dependent microtubule sliding in budding yeast.Journal of cell science · 2020Article
- Stochastic Model of T Cell Repolarization during Target Elimination I.Biophysical journal · 2020Article
- Cortical tethering of mitochondria by the anchor protein Mcp5 enables uniparental inheritance.The Journal of cell biology · 2019Article
- A conserved mechanism for mitochondria-dependent dynein anchoring.Molecular biology of the cell · 2019Article
- Nuclear movement in fungi.Seminars in cell & developmental biology · 2018Review
- Cortical dynein pulling mechanism is regulated by differentially targeted attachment molecule Num1.eLife · 2018Article
- Moving and stopping: Regulation of chromosome movement to promote meiotic chromosome pairing and synapsis.Nucleus (Austin, Tex.) · 2017Review
- Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport.PLoS genetics · 2017Article
- Fission yeast myosin I facilitates PI(4,5)PProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Microtubule minus end motors kinesin-14 and dynein drive nuclear congression in parallel pathways.The Journal of cell biology · 2015Article
- Dynein, microtubule and cargo: a ménage à trois.Biochemical Society transactions · 2013Review
- A novel patch assembly domain in Num1 mediates dynein anchoring at the cortex during spindle positioning.The Journal of cell biology · 2012Article
- Function of dynein in budding yeast: mitotic spindle positioning in a polarized cell.Cell motility and the cytoskeleton · 2009Review
- Self-organization of dynein motors generates meiotic nuclear oscillations.PLoS biology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During meiotic prophase I of the fission yeast Schizosaccharomyces pombe, oscillatory nuclear movement occurs. This promotes homologous chromosome pairing and recombination and involves cortical dynein, which plays a pivotal role by generating a pulling force with the help of an unknown dynein anchor. We show that Mcp5, the homologue of the budding yeast dynein anchor Num1, may be this putative dynein anchor. mcp5+ is predominantly expressed during meiotic prophase, and GFP-Mcp5 localizes at the cell cortex. Moreover, the mcp5Delta strain lacks the oscillatory nuclear movement. Accordingly, homologous pairing and recombination rates of the mcp5Delta strain are significantly reduced. Furthermore, the cortical localization of dynein heavy chain 1 appears to be reduced in mcp5Delta cells. Finally, the full function of Mcp5 requires its coiled-coil and pleckstrin homology (PH) domains. Our results suggest that Mcp5 localizes at the cell cortex through its PH domain and functions as a dynein anchor, thereby facilitating nuclear oscillation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.