ArticleBMC genetics2006
A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains.
Article in BMC genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetic quality assurance and genetic monitoring of laboratory mice and rats: FELASA Working Group Report.Laboratory animals · 2020Guideline
- Standards and pitfalls of focal ischemia models in spontaneously hypertensive rats: with a systematic review of recent articles.Journal of translational medicine · 2012Pooled it
- Diverse Cre recombinase expression pattern in Albumin-Cre driver rats.Experimental animals · 2025Article
- Identification of the genetic background of laboratory rats through amplicon-based next-generation sequencing for single-nucleotide polymorphism genotyping.BMC genomic data · 2024Article
- A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats.Cell genomics · 2024Article
- A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats.bioRxiv : the preprint server for biology · 2023Article
- A Genetically Heterogeneous Rat Model with Divergent Mitochondrial Genomes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Genetic profiling of two phenotypically distinct outbred rats derived from a colony of the Zucker fatty rats maintained at Tokyo Medical University.Experimental animals · 2017Article
- Design and application of a target capture sequencing of exons and conserved non-coding sequences for the rat.BMC genomics · 2016Article
- Slc:Wistar outbred rats show close genetic similarity with F344 inbred rats.Experimental animals · 2015Article
- Article
- Genetic and phenotypic characterization of a Japanese wild-derived DOB/Oda rat strain.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Identification of QTLs involved in the development of amygdala kindling in the rat.Experimental animals · 2013Article
- Systematic polymorphism discovery after genome-wide identification of potential susceptibility loci in a hereditary rodent model of human hypertension.Blood pressure · 2011Article
- Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats.Physiological genomics · 2010Article
- Strain differences in delay discounting using inbred rats.Genes, brain, and behavior · 2009Article
- An informative set of SSLP markers and genomic profiles in the rat MHC, the RT1 complex.Immunogenetics · 2009Article
- Multiplex microsatellite marker panels for genetic monitoring of common rat strains.Journal of the American Association for Laboratory Animal Science : JAALAS · 2008Article
- SNP and haplotype mapping for genetic analysis in the rat.Nature genetics · 2008Article
- A genome-wide SNP panel for mapping and association studies in the rat.BMC genomics · 2008Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe National Bio Resource Project for the Rat in Japan (NBRP-Rat) is focusing on collecting, preserving and distributing various rat strains, including spontaneous mutant, transgenic, congenic, and recombinant inbred (RI) strains. To evaluate their value as models of human diseases, we are characterizing them using 109 phenotypic parameters, such as clinical measurements, internal anatomy, metabolic parameters, and behavioral tests, as part of the Rat Phenome Project. Here, we report on a set of 357 simple sequence length polymorphism (SSLP) markers and 122 rat strains, which were genotyped by the marker set.
resultsThe SSLP markers were selected according to their distribution patterns throughout the whole rat genome with an average spacing of 7.59 Mb. The average number of informative markers between all possible pairs of strains was 259 (72.5% of 357 markers), showing their high degree of polymorphism. From the genetic profile of these rat inbred strains, we constructed a rat family tree to clarify their genetic background.
conclusionThese highly informative SSLP markers as well as genetically and phenotypically defined rat strains are useful for designing experiments for quantitative trait loci (QTL) analysis and to choose strategies for developing new genetic resources. The data and resources are freely available at the NBRP-Rat web site 1.
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