ArticleJournal of virology1991
Translational control of human cytomegalovirus gp48 expression.
Article in Journal of virology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed.
- Calcium and Cadmium Activate ESRRB to Mediate Cell Stemness and Pluripotency.International journal of molecular sciences · 2025Article
- Reverse genetics-based biochemical studies of the ribosomal exit tunnel constriction region in eukaryotic ribosome stalling: spatial allocation of the regulatory nascent peptide at the constriction.Nucleic acids research · 2020Article
- Assessing the translational landscape of myogenic differentiation by ribosome profiling.Nucleic acids research · 2015Article
- The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene.PloS one · 2010Article
- Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1.Journal of virology · 2003Article
- A novel CC-chemokine homolog encoded by guinea pig cytomegalovirus.Virus genes · 2002Article
- Identification of glycoprotein gpTRL10 as a structural component of human cytomegalovirus.Journal of virology · 2002Article
- Critical roles of nuclear receptor response elements in replication of hepatitis B virus.Journal of virology · 2001Article
- Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR.Nucleic acids research · 2001Article
- Abundant early expression of gpUL4 from a human cytomegalovirus mutant lacking a repressive upstream open reading frame.Journal of virology · 2001Article
- Upstream open reading frames as regulators of mRNA translation.Molecular and cellular biology · 2000Review
- Termination and peptide release at the upstream open reading frame are required for downstream translation on synthetic shunt-competent mRNA leaders.Molecular and cellular biology · 2000Article
- Activation of the myc oncoprotein leads to increased turnover of thrombospondin-1 mRNA.Nucleic acids research · 2000Article
- Ribosome shunting in the cauliflower mosaic virus 35S RNA leader is a special case of reinitiation of translation functioning in plant and animal systems.Genes & development · 2000Article
- Complementarity between the mRNA 5' untranslated region and 18S ribosomal RNA can inhibit translation.RNA (New York, N.Y.) · 2000Article
- The amino-terminus and membrane-spanning domains of LMP-1 inhibit cell proliferation.Oncogene · 2000Article
- Translational effects of mutations and polymorphisms in a repressive upstream open reading frame of the human cytomegalovirus UL4 gene.Journal of virology · 1999Article
- The linking regions of EBNA1 are essential for its support of replication and transcription.Molecular and cellular biology · 1999Article
- The plasmid replicon of EBV consists of multiple cis-acting elements that facilitate DNA synthesis by the cell and a viral maintenance element.The EMBO journal · 1998Article
- Inefficient reinitiation is responsible for upstream open reading frame-mediated translational repression of the maize R gene.The Plant cell · 1998Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Posttranscriptional controls modulate the expression of several human cytomegalovirus genes. Previous studies have shown that one cytomegalovirus gene transcript leader contains AUG codons which inhibit translation of a downstream reading frame. However, two other cytomegalovirus gene transcript leaders of similar structure do not inhibit translation. We have extended these studies to the analysis of the structural glycoprotein gp48, whose predominant transcript contains three upstream AUG codons. The 5' leader of this transcript strongly inhibits downstream translation in fibroblasts. Analyses of deletions and point mutations identify the second upstream AUG codon as an essential component of the inhibitory signal. Other leader sequences, but neither the first nor the third AUG codon, are also required. Intriguingly, the inhibitory signal appears also to depend on the amino acid coding information of the short reading frame associated with the second AUG codon. Insights derived from these studies are germane to understanding the translational regulation of other viral and cellular genes of similar structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.