ArticlePediatric nephrology (Berlin, Germany)2006
Calcium and phosphate balance in adolescents on home nocturnal haemodialysis.
Article in Pediatric nephrology (Berlin, Germany), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The dietary management of calcium and phosphate in children with CKD stages 2-5 and on dialysis-clinical practice recommendation from the Pediatric Renal Nutrition Taskforce.Pediatric nephrology (Berlin, Germany) · 2020Guideline
- Evidence-Based Guidelines for the Diagnosis and Treatment of Pediatric CKD-Mineral and Bone Disorder (Version 2024).Kidney international reports · 2026Article
- Executive Summary of Evidence-Based Guidelines for the Diagnosis and Treatment of Pediatric CKD-Mineral and Bone Disorder (Version 2024).Kidney international reports · 2026Article
- Comparing outcomes with different dialysis modalities in children with kidney failure: home hemodialysis versus in-center hemodiafiltration or conventional hemodialysis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Is home best when it comes to pediatric hemodialysis?Pediatric nephrology (Berlin, Germany) · 2026Article
- How dialysis frequency and duration impact uremic toxin and fluid removal: a pediatric perspective.Pediatric nephrology (Berlin, Germany) · 2025Review
- Monitoring dialysis adequacy: history and current practice.Pediatric nephrology (Berlin, Germany) · 2021Article
- Reducing the burden of cardiovascular disease in children with chronic kidney disease: prevention vs. damage limitation.Pediatric nephrology (Berlin, Germany) · 2021Review
- Hemodiafiltration in a pediatric nocturnal dialysis program.Pediatric nephrology (Berlin, Germany) · 2014Article
- Intensified hemodialysis in adults, and in children and adolescents.Deutsches Arzteblatt international · 2014Review
- Home haemodialysis.Pediatric nephrology (Berlin, Germany) · 2013Review
- Chronic kidney disease: mineral and bone disorder in children.Seminars in nephrology · 2013Review
- Can dialysis modality influence cardiovascular outcome?Pediatric nephrology (Berlin, Germany) · 2012Article
- Approach to the hypophosphatemic patient.The Journal of clinical endocrinology and metabolism · 2012Article
- Mineral metabolism and bone abnormalities in children with chronic renal failure.Reviews in endocrine & metabolic disorders · 2008Review
- How have the past 5 years of research changed clinical practice in paediatric nephrology?Archives of disease in childhood · 2007Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies in adults show superior serum phosphate and parathyroid hormone (PTH) control on slow nocturnal haemodialysis (NHD) compared with conventional haemodialysis. We studied the progress of four children aged 12, 13, 14 and 16 years after they had been initiated on NHD. The follow-up period ranged from 6 months to 20 months. Biochemical indices of bone metabolism were collected prospectively. All four children were initially dialysed against a 1.5 mmol/l calcium bath. In two patients, owing to biochemical hypocalcaemic episodes, the dialysate calcium concentration was increased to 1.75 mmol/l. One patient became hypercalcaemic and received calcitonin for bone pain secondary to osteoporosis and was dialysed against a 1.0 mmol/l calcium bath. Including an evaluation of dietary intake, all four patients had a net positive calcium balance, ranging from 5.1 mmol/m2 body surface area (BSA) per day to 24.3 mmol/m2 BSA per day. A significant reduction in the pre-dialysis phosphate level was observed in all four patients, such that none required dietary restrictions or phosphate binders, and dialysate phosphate supplements of 0.8-2.03 mmol/l were employed to prevent hypophosphataemia. The (CaxPO4) dropped below 4.4 mmol(2) l(-2) in all four patients. Concurrently, significant reductions in intact PTH levels were seen in all four patients, but the level dropped to below normal range in two. In our cohort of patients, NHD rapidly lowered plasma phosphate and PTH levels, and additional dialysate phosphate and possibly calcium may be necessary to prevent bone demineralisation due to chronic losses and to prevent oversuppression of PTH.
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Registered trials
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