ArticleChromosoma2006
DNA underreplication in intercalary heterochromatin regions in polytene chromosomes of Drosophila melanogaster correlates with the formation of partial chromosomal aberrations and ectopic pairing.
Article in Chromosoma, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Expanding the HP1a-binding consensus and molecular grammar for heterochromatin assembly.Nucleic acids research · 2025Article
- Chromatin Structure and "DNA Sequence View": The Role of Satellite DNA in Ectopic Pairing of theInternational journal of molecular sciences · 2021Article
- Article
- Arp2/3 and Unc45 maintain heterochromatin stability inExperimental biology and medicine (Maywood, N.J.) · 2019Article
- Article
- Article
- Article
- Late replication domains in polytene and non-polytene cells of Drosophila melanogaster.PloS one · 2012Article
- Cytogenetic analysis of the Ethiopian fruit fly Dacus ciliatus (Diptera: Tephritidae).Genetica · 2011Article
- Article
- Drosophila D1 overexpression induces ectopic pairing of polytene chromosomes and is deleterious to development.Chromosoma · 2010Article
- Article
- Essential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Review
- Local DNA underreplication correlates with accumulation of phosphorylated H2Av in the Drosophila melanogaster polytene chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- The mutation of the Suppressor of Underreplication gene does not affect the replication fork rate in the Drosophila melanogaster salivary gland polytene chromosomes.Doklady. Biochemistry and biophysicsArticle
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the influence of the Suppressor of Underreplication (SuUR) gene expression on the intercalary heterochromatin (IH) regions of Drosophila melanogaster polytene chromosomes. We observed a strong positive correlation between increased SuUR expression, underreplication extent, amount of DNA truncation, and formation of ectopic contacts in IH regions. SuUR overexpression from heat shock-driven transgene results in the formation of partial chromosomal aberrations whose breakpoints map exclusively to the regions of intercalary and pericentric heterochromatin. It is important to note that all these effects are seen only if SuUR overexpression is induced during early stages of chromosome polytenization. Therefore, we developed the idea that ectopic pairing results from the joining of free DNA ends, which are formed as a consequence of underreplication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.