Evidence map›Paper›PMID 16583159›Full record

ArticleNeuroscience and behavioral physiology2006

Acquisition and extinction of a conditioned passive avoidance reflex in mice with genetic knockout of monoamine oxidase A.

N I Dubrovina, N K Popova, M A Gilinskii, R A Tomilenko, I Seif

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Neuroscience and behavioral physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Plasticity of Functional MAOA Gene Methylation in Acrophobia.The international journal of neuropsychopharmacology · 2018
    Article
  4. Review
  5. Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013
    Article
  6. Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

N I DubrovinaState Science Research Institute of Physiology, Siberian Division, Russian Academy of Medical Sciences.
N K Popova
M A Gilinskii
R A Tomilenko
I Seif
Russian Academy of Sciences · RUCentre National de la Recherche Scientifique · FRInstitut Curie · FRResearch Institute of Physiology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Medical Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report here the results obtained from comparative analysis of learning and the dynamics of extinction of a conditioned passive avoidance response in mice with genetic knockout of monoamine oxidase A (MAO A) and the progenitor line C3H. Mice of both lines acquired the conditioned passive avoidance reaction efficiently. Mice with genetic knockout of MAO A were characterized by prolonged retention of reproduction of the memory trace, as compared with rapid extinction in C3H mice. Smaller numbers of transfers, and vertical rearings on days 7-13 and the numbers of glances into and rom the dark sector on days 11-13 of extinction in MAO A-knockout mice appear to reflect their more marked fear reactions when confronted with the "dangerous" sector, along with increased anxiety, these facilitating longer-lasting retention of the memory trace.

Indexed as

Analysis of VarianceAnimalsAvoidance LearningBehavior, AnimalEscape ReactionExtinction, PsychologicalMiceMice, Inbred C3HMice, KnockoutMonoamine OxidaseRetention, PsychologyMonoamine Oxidase

Identifiers

PMID16583159
OpenAlexW2082686361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.