ArticleMolecular and cellular biochemistry2006
Effects of carbenoxolone on heart rhythm, contractility and intracellular calcium in streptozotocin-induced diabetic rat.
Article in Molecular and cellular biochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 28 citations in OpenAlex.
- Analgesic and anti-inflammatory properties of carbenoxolone: a review.Inflammopharmacology · 2025Review
- Initiation and entrainment of multicellular automaticity via diffusion limited extracellular domains.Biophysical journal · 2021Article
- Calcium signaling in endocardial and epicardial ventricular myocytes from streptozotocin-induced diabetic rats.Journal of diabetes investigation · 2021Article
- Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices.Scientific reports · 2018Article
- Pigment Epithelium-Derived Factor (PEDF) Improves Ischemic Cardiac Functional Reserve Through Decreasing Hypoxic Cardiomyocyte Contractility Through PEDF Receptor (PEDF-R).Journal of the American Heart Association · 2016Article
- Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat.PloS one · 2016Article
- Cardiac myocyte alternans in intact heart: Influence of cell-cell coupling and β-adrenergic stimulation.Journal of molecular and cellular cardiology · 2015Article
- Upregulation of arginase activity contributes to intracellular ROS production induced by high glucose in H9c2 cells.International journal of clinical and experimental pathology · 2015Article
- Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats.Cardiovascular diabetology · 2013Article
- Diabetes increases mortality after myocardial infarction by oxidizing CaMKII.The Journal of clinical investigation · 2013Article
- Altered gene expression may underlie prolonged duration of the QT interval and ventricular action potential in streptozotocin-induced diabetic rat heart.Molecular and cellular biochemistry · 2009Article
- Altered calcium homeostasis does not explain the contractile deficit of diabetic cardiomyopathy.Diabetes · 2008Article
- Altered expression of gap junction connexin proteins may partly underlie heart rhythm disturbances in the streptozotocin-induced diabetic rat heart.Molecular and cellular biochemistry · 2007Article
- Effects of streptozotocin-induced diabetes on action potentials in the sinoatrial node compared with other regions of the rat heart.Molecular and cellular biochemistry · 2007Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Cardiac dysfunction is a frequently reported complication of clinical and experimental diabetes mellitus. Streptozotocin (STZ)-induced diabetes in rat is associated with a variety of cardiac defects including disturbances to heart rhythm and prolonged time-course of cardiac muscle contraction and/or relaxation. The effects of carbenoxolone (CBX), a selective gap junction inhibitor, on heart rhythm and contractility in STZ-induced diabetic rat have been investigated. Heart rate was significantly (P < 0.05) reduced in Langendorff perfused spontaneously beating diabetic rat heart (171+/-12 BPM) compared to age-matched controls (229+/- 9 BPM) and further reduced by 10(-5) M CBX in diabetic (20%) and in control (17%) hearts. Action potential durations (APDs), recorded on the epicardial surface of the left ventricle, were prolonged in paced (6 Hz) diabetic compared to control hearts. Perfusion of hearts with CBX caused further prolongation of APDs and to a greater extent in control compared to diabetic heart. Percentage prolongation at 70% from the peak of the action potential amplitude after CBX was 18% in diabetic compared to 48% in control heart. CBX had no significant effect on resting cell length or amplitude of ventricular myocyte shortening in diabetic or control rats. However, resting fura-2 ratio (indicator for intracellular Ca(2+) concentration) and amplitude of the Ca(2+) transient were significantly (P < 0.05) reduced by CBX in diabetic rats but not in controls. In conclusion the larger effects of CBX on APD in control ventricle and the normalizing effects of CBX on intracellular Ca(2+) in ventricular myocytes from diabetic rat suggest that there may be alterations in gap junction electrophysiology in STZ-induced diabetic rat heart.
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