ArticleGenetics2006
Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- Non-Mendelian inheritance of DNA methylation patterns in mice.Nature genetics · 2026Article
- Escape from X inactivation drives sex differences in gene expression.Molecular biology and evolution · 2026Article
- A long noncoding RNA influences the choice of the X chromosome to be inactivated.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Elastic dosage compensation by X-chromosome upregulation.Nature communications · 2022Article
- Review
- Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages.Developmental cell · 2021Article
- Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution.Nature communications · 2021Article
- Article
- X-chromosome upregulation is driven by increased burst frequency.Nature structural & molecular biology · 2019Article
- Article
- Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation.Genome research · 2016Article
- Cis- and trans-regulation in X inactivation.Chromosoma · 2016Review
- The Effects of Genetic Background of Mouse Models of Cancer: Friend or Foe?Cold Spring Harbor protocols · 2016Article
- Sex-specific silencing of X-linked genes by Xist RNA.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Allelome.PRO, a pipeline to define allele-specific genomic features from high-throughput sequencing data.Nucleic acids research · 2015Article
- A Primary Role for the Tsix lncRNA in Maintaining Random X-Chromosome Inactivation.Cell reports · 2015Article
- A novel multi-alignment pipeline for high-throughput sequencing data.Database : the journal of biological databases and curation · 2014Article
- Hybrid mice reveal parent-of-origin and Cis- and trans-regulatory effects in the retina.PloS one · 2014Article
- Genetic architecture of skewed X inactivation in the laboratory mouse.PLoS genetics · 2013Article
- Nonrandom X chromosome inactivation is influenced by multiple regions on the murine X chromosome.Genetics · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In early mammalian development, one of the two X chromosomes is silenced in each female cell as a result of X chromosome inactivation, the mammalian dosage compensation mechanism. In the mouse epiblast, the choice of which chromosome is inactivated is essentially random, but can be biased by alleles at the X-linked X controlling element (Xce). Although this locus was first described nearly four decades ago, the identity and precise genomic localization of Xce remains elusive. Within the X inactivation center region of the X chromosome, previous linkage disequilibrium studies comparing strains of known Xce genotypes have suggested that Xce is physically distinct from Xist, although this has not yet been established by genetic mapping or progeny testing. In this report, we used quantitative trait locus (QTL) mapping strategies to define the minimal Xce candidate interval. Subsequent analysis of recombinant chromosomes allowed for the establishment of a maximum 1.85-Mb candidate region for the Xce locus. Finally, we use QTL approaches in an effort to identify additional modifiers of the X chromosome choice, as we have previously demonstrated that choice in Xce heterozygous females is significantly influenced by genetic variation present on autosomes (Chadwick and Willard 2005). We did not identify any autosomal loci with significant associations and thus show conclusively that Xce is the only major locus to influence X inactivation patterns in the crosses analyzed. This study provides a foundation for future analyses into the genetic control of X chromosome inactivation and defines a 1.85-Mb interval encompassing all the major elements of the Xce locus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.