ArticleThe Plant cell2006
Arabidopsis separase AESP is essential for embryo development and the release of cohesin during meiosis.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 73 citations in OpenAlex.
- Polyploid Formation Through Disrupting Mitotic Sister Chromatid Separation of Spermatogonia based on espl1 Heterozygous Knockout in Fish.Molecular biology and evolution · 2025Article
- Article
- The Role of Anaphase-Promoting Complex/Cyclosome (APC/C) in Plant Reproduction.Frontiers in plant science · 2021Review
- Epigenetics Regulates Reproductive Development in Plants.Plants (Basel, Switzerland) · 2019Review
- Article
- Patronus is the elusive plant securin, preventing chromosome separation by antagonizing separase.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Maternal control of seed weight in rapeseed (Brassica napus L.): the causal link between the size of pod (mother, source) and seed (offspring, sink).Plant biotechnology journal · 2019Article
- Interregulation of CDKA/CDK1 and the Plant-Specific Cyclin-Dependent Kinase CDKB in Control of the Chlamydomonas Cell Cycle.The Plant cell · 2018Article
- Loss of function of Arabidopsis microRNA-machinery genes impairs fertility, and has effects on homologous recombination and meiotic chromatin dynamics.Scientific reports · 2017Article
- In Favor of Establishment: Regulation of Chromatid Cohesion in Plants.Frontiers in plant science · 2017Review
- Separase Is Required for Homolog and Sister Disjunction during Drosophila melanogaster Male Meiosis, but Not for Biorientation of Sister Centromeres.PLoS genetics · 2016Article
- The Opposing Actions of Arabidopsis CHROMOSOME TRANSMISSION FIDELITY7 and WINGS APART-LIKE1 and 2 Differ in Mitotic and Meiotic Cells.The Plant cell · 2016Article
- BnaC9.SMG7b Functions as a Positive Regulator of the Number of Seeds per Silique in Brassica napus by Regulating the Formation of Functional Female Gametophytes.Plant physiology · 2015Article
- PATRONUS1 is expressed in meiotic prophase I to regulate centromeric cohesion in Arabidopsis and shows synthetic lethality with OSD1.BMC plant biology · 2015Article
- Arabidopsis thaliana WAPL is essential for the prophase removal of cohesin during meiosis.PLoS genetics · 2014Article
- SUMO E3 ligase AtMMS21 is required for normal meiosis and gametophyte development in Arabidopsis.BMC plant biology · 2014Article
- Chromosome segregation in plant meiosis.Frontiers in plant science · 2014Review
- Histone deacetylase AtHDA7 is required for female gametophyte and embryo development in Arabidopsis.Plant physiology · 2013Article
- The caspase-related protease separase (extra spindle poles) regulates cell polarity and cytokinesis in Arabidopsis.The Plant cell · 2013Article
- A single cohesin complex performs mitotic and meiotic functions in the protist tetrahymena.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate how and when sister chromatid cohesion is released from chromosomes in plants, we isolated the Arabidopsis thaliana homolog of separase (AESP) and investigated its role in somatic and meiotic cells. AESP is similar to separase proteins identified in other organisms but contains several additional structural motifs. The characterization of two Arabidopsis T-DNA insertion alleles for AESP demonstrated that it is an essential gene. Seeds homozygous for T-DNA insertions in AESP exhibited embryo arrest at the globular stage. The endosperm also exhibited a weak titan-like phenotype. Transgenic plants expressing AESP RNA interference (RNAi) from the meiosis-specific DMC1 promoter exhibited alterations in chromosome segregation during meiosis I and II that resulted in polyads containing from one to eight microspores. Consistent with its predicted role in the release of sister chromatid cohesion, immunolocalization studies showed that the removal of SYN1 from chromosome arms and the centromeres is inhibited in the RNAi mutants. However, the release of SYN1 during diplotene occurred normally, indicating that this process is independent of AESP. Therefore, our results demonstrate that AESP plays an essential role in embryo development and provide direct evidence that AESP is required for the removal of cohesin from meiotic chromosomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.