ArticleThe Plant cell2006
The plastid protein THYLAKOID FORMATION1 and the plasma membrane G-protein GPA1 interact in a novel sugar-signaling mechanism in Arabidopsis.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed, 200 citations in OpenAlex.
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- Genome-wide association studies provide genetic insights into natural variation of seed-size-related traits in mungbean.Frontiers in plant science · 2022Article
- Molecular Characterization of NDL1-AGB1 Mediated Salt Stress Signaling: Further Exploration of the Role ofCells · 2021Article
- Heterotrimeric G-protein α subunit (RGA1) regulates tiller development, yield, cell wall, nitrogen response and biotic stress in rice.Scientific reports · 2021Article
- SPLICING FACTOR1 Is Important in Chloroplast Development under Cold Stress.Plant physiology · 2020Article
- The CsGPA1-CsAQPs module is essential for salt tolerance of cucumber seedlings.Plant cell reports · 2020Article
- MOS1 Negatively Regulates Sugar Responses and Anthocyanin Biosynthesis in Arabidopsis.International journal of molecular sciences · 2020Article
- Plant G-protein signaling cascade and host defense.3 Biotech · 2020Review
- Two Chloroplast Proteins Negatively Regulate Plant Drought Resistance Through Separate Pathways.Plant physiology · 2020Article
- Family-Specific Gains and Losses of Protein Domains in the Legume and Grass Plant Families.Evolutionary bioinformatics online · 2020Article
- Photosynthesis in a Changing Global Climate: Scaling Up and Scaling Down in Crops.Frontiers in plant science · 2020Review
- Glucose-RegulatedPlant physiology · 2019Article
- Chloroplast vesicle transport.Photosynthesis research · 2018Review
- Characterization of Heterotrimeric G Protein γ4 Subunit in Rice.International journal of molecular sciences · 2018Article
- Identification of Heterotrimeric G Protein γ3 Subunit in Rice Plasma Membrane.International journal of molecular sciences · 2018Article
29 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Mutations in genes encoding components of the heterotrimeric G-protein complex were previously shown to confer altered sensitivity to increased levels of D-glucose. This suggests that G-protein coupling may be a novel sugar-signaling mechanism in Arabidopsis thaliana. THYLAKOID FORMATION1 (THF1) is here demonstrated in vivo as a Galpha interaction partner that functions downstream of the plasma membrane-delimited heterotrimeric G-protein (GPA1) in a D-glucose signaling pathway. THF1 is a plastid protein localized to both the outer plastid membrane and the stroma. Contact between root plastidic THF1 and GPA1 at the plasma membrane occurs at sites where the plastid membrane abuts the plasma membrane, as demonstrated by Förster resonance energy transfer (FRET). A probable role for THF1 in sugar signaling is demonstrated by both biochemical and genetic evidence. Root growth in the thf1-1 null mutant is hypersensitive to exogenous D-glucose, and THF1-overexpressing roots are resistant to inhibition of growth rate by high D-glucose. Additionally, THF1 levels are rapidly degraded by D-glucose but not L-glucose. The interaction between THF1 and GPA1 has been confirmed by in vitro and in vivo coimmunoprecipitation, FRET analysis, and genetic epistasis and provides evidence of a sugar-signaling mechanism between plastids and the plasma membrane.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.