ArticleProceedings of the National Academy of Sciences of the United States of America2006
Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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64 citing papers in PubMed.
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- Evolution of hypoxia and hypoxia-inducible factor asparaginyl hydroxylase regulation in chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
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- Down-regulation of human long non-coding RNA LINC01187 is associated with nephropathies.Journal of cellular and molecular medicine · 2023Article
- Expanded Hemodialysis ameliorates uremia-induced impairment of vasculoprotective KLF2 and concomitant proinflammatory priming of endothelial cells through an ERK/AP1/cFOS-dependent mechanism.Frontiers in immunology · 2023Article
- GDF15 Suppresses Lymphoproliferation and Humoral Autoimmunity in a Murine Model of Systemic Lupus Erythematosus.Journal of innate immunity · 2022Article
- The ShGlomFrontiers in cell and developmental biology · 2022Article
- ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage.Journal of the American Society of Nephrology : JASN · 2021Article
- Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development.International journal of molecular sciences · 2021Article
- Nuclear receptors in podocyte biology and glomerular disease.Nature reviews. Nephrology · 2021Review
- Transcriptional regulation of prolactin in a euryhaline teleost: Characterisation of gene promoters through in silico and transcriptome analyses.Journal of neuroendocrinology · 2020Review
- Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice.International journal of molecular sciences · 2020Article
- Dysregulated mesenchymal PDGFR-β drives kidney fibrosis.EMBO molecular medicine · 2020Article
- mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.JCI insight · 2019Article
- Tubular NOX4 expression decreases in chronic kidney disease but does not modify fibrosis evolution.Redox biology · 2019Article
- A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury.Journal of the American Society of Nephrology : JASN · 2019Article
- A KDM6A-KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction.EMBO molecular medicine · 2019Article
4 more citing papers are in PubMed but not listed here.
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14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Shared transcription factor binding sites that are conserved in distance and orientation help control the expression of gene products that act together in the same biological context. New bioinformatics approaches allow the rapid characterization of shared promoter structures and can be used to find novel interacting molecules. Here, these principles are demonstrated by using molecules linked to the unique functional unit of the glomerular slit diaphragm. An evolutionarily conserved promoter model was generated by comparative genomics in the proximal promoter regions of the slit diaphragm-associated molecule nephrin. Phylogenetic promoter fingerprints of known elements of the slit diaphragm complex identified the nephrin model in the promoter region of zonula occludens-1 (ZO-1). Genome-wide scans using this promoter model effectively predicted a previously unrecognized slit diaphragm molecule, cadherin-5. Nephrin, ZO-1, and cadherin-5 mRNA showed stringent coexpression across a diverse set of human glomerular diseases. Comparative promoter analysis can identify regulatory pathways at work in tissue homeostasis and disease processes.
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