ArticleProceedings of the National Academy of Sciences of the United States of America2006
Reactivation by exon shuffling of a conserved HLA-DR3-like pseudogene segment in a New World primate species.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Evolution of HLA-F and its orthologues in primate species: a complex tale of conservation, diversification and inactivation.Immunogenetics · 2020Article
- Experimental autoimmune encephalomyelitis in the common marmoset: a translationally relevant model for the cause and course of multiple sclerosis.Primate biology · 2019Review
- Comparative immunity of antigen recognition, differentiation, and other functional molecules: similarities and differences among common marmosets, humans, and mice.Experimental animals · 2018Review
- Characterization of the peripheral blood transcriptome and adaptive evolution of the MHC I and TLR gene families in the wolf (Canis lupus).BMC genomics · 2017Article
- Major Histocompatibility Complex Genes Map to Two Chromosomes in an Evolutionarily Ancient Reptile, the Tuatara Sphenodon punctatus.G3 (Bethesda, Md.) · 2015Article
- Advantages and Risks of Husbandry and Housing Changes to Improve Animal Wellbeing in a Breeding Colony of Common Marmosets (Callithrix jacchus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- The primate autoimmune encephalomyelitis model; a bridge between mouse and man.Annals of clinical and translational neurology · 2015Review
- The repertoire of MHC class I genes in the common marmoset: evidence for functional plasticity.Immunogenetics · 2013Article
- The Primate EAE Model Points at EBV-Infected B Cells as a Preferential Therapy Target in Multiple Sclerosis.Frontiers in immunology · 2013Article
- Antibodies against human BLyS and APRIL attenuate EAE development in marmoset monkeys.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- Extensive DRB region diversity in cynomolgus macaques: recombination as a driving force.Immunogenetics · 2010Article
- The chimpanzee Mhc-DRB region revisited: gene content, polymorphism, pseudogenes, and transcripts.Molecular immunology · 2009Article
- Correlated evolution of nucleotide substitution rates and allelic variation in Mhc-DRB lineages of primates.BMC evolutionary biology · 2009Article
- Divergent patterns of selection on the DAB and DXB MHC class II loci in Xiphophorus fishes.Genetica · 2009Article
- Pseudofam: the pseudogene families database.Nucleic acids research · 2009Article
- Article
- Comparative genetics of a highly divergent DRB microsatellite in different macaque species.Immunogenetics · 2008Article
- Characterization of expressed class II MHC sequences in the banner-tailed kangaroo rat (Dipodomys spectabilis) reveals multiple DRB loci.Immunogenetics · 2008Article
- Article
- Impact of endogenous intronic retroviruses on major histocompatibility complex class II diversity and stability.Journal of virology · 2008Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The common marmoset (Callithrix jacchus), a New World monkey species with a limited MHC class II repertoire, is highly susceptible to certain bacterial infections. Genomic analysis of exon 2 sequences documented the existence of only one DRB region configuration harboring three loci. Two of these loci display moderate levels of allelic polymorphism, whereas the -DRB*W12 gene appears to be monomorphic. This study shows that only the Caja-DRB*W16 and -DRB*W12 loci produce functional transcripts. The Caja-DRB1*03 locus is occupied by a pseudogene, given that most of the transcripts, if detected at all, show imperfections and are present at low levels. Moreover, two hybrid transcripts were identified that feature the evolutionarily conserved peptide-binding motif characteristic for the Caja-DRB1*03 gene. Thus, the severely reduced MHC class II repertoire in common marmosets has been expanded by reactivation of a pseudogene segment as a result of exon shuffling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.