ArticlePlant physiology2006
The shoot-specific expression of gamma-glutamylcysteine synthetase directs the long-distance transport of thiol-peptides to roots conferring tolerance to mercury and arsenic.
Article in Plant physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Glutathione Relevance in the Response of CiliateBiology · 2026Article
- Mitigating toxic metals contamination in foods: Bridging knowledge gaps for addressing food safety.Trends in food science & technology · 2024Article
- Phytochelatins: Sulfur-Containing Metal(loid)-Chelating Ligands in Plants.International journal of molecular sciences · 2023Review
- Review
- Heterologous Expression of the Phytochelatin SynthaseInternational journal of environmental research and public health · 2022Article
- ARSENATE INDUCED CHLOROSIS 1/ TRANSLOCON AT THE OUTER ENVOLOPE MEMBRANE OF CHLOROPLASTS 132 Protects Chloroplasts from Arsenic Toxicity.Plant physiology · 2018Article
- Dissecting the components controlling root-to-shoot arsenic translocation in Arabidopsis thaliana.The New phytologist · 2018Article
- Protective effect exerted by soil phosphorus on soybean subjected to arsenic and fluoride.Redox report : communications in free radical research · 2017Article
- Identification of alternatively spliced transcripts of rice phytochelatin synthase 2 gene OsPCS2 involved in mitigation of cadmium and arsenic stresses.Plant molecular biology · 2017Article
- Accumulation and transformation of inorganic and organic arsenic in rice and role of thiol-complexation to restrict their translocation to shoot.Scientific reports · 2017Article
- Exogenous Glutathione Enhances Mercury Tolerance by Inhibiting Mercury Entry into Plant Cells.Frontiers in plant science · 2017Article
- Jacks of metal/metalloid chelation trade in plants-an overview.Frontiers in plant science · 2015Review
- Arabidopsis thaliana phytochelatin synthase 2 is constitutively active in vivo and can rescue the growth defect of the PCS1-deficient cad1-3 mutant on Cd-contaminated soil.Journal of experimental botany · 2014Article
- Cadmium exposure and sulfate limitation reveal differences in the transcriptional control of three sulfate transporter (Sultr1;2) genes in Brassica juncea.BMC plant biology · 2014Article
- Metal species involved in long distance metal transport in plants.Frontiers in plant science · 2014Review
- Cloning and characterization of a Phragmites australis phytochelatin synthase (PaPCS) and achieving Cd tolerance in tall fescue.PloS one · 2014Article
- Expression of Ceratophyllum demersum phytochelatin synthase, CdPCS1, in Escherichia coli and Arabidopsis enhances heavy metal(loid)s accumulation.Protoplasma · 2013Article
- Cesium Inhibits Plant Growth through Jasmonate Signaling in Arabidopsis thaliana.International journal of molecular sciences · 2013Article
- Hijacking membrane transporters for arsenic phytoextraction.Journal of biotechnology · 2013Article
- A phenomics approach to the analysis of the influence of glutathione on leaf area and abiotic stress tolerance in Arabidopsis thaliana.Frontiers in plant science · 2013Article
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5 authors.
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Abstract
Thiol-peptides synthesized as intermediates in phytochelatin (PC) biosynthesis confer cellular tolerance to toxic elements like arsenic, mercury, and cadmium, but little is known about their long-distance transport between plant organs. A modified bacterial gamma-glutamylcysteine synthetase (ECS) gene, S1ptECS, was expressed in the shoots of the ECS-deficient, heavy-metal-sensitive cad2-1 mutant of Arabidopsis (Arabidopsis thaliana). S1ptECS directed strong ECS protein expression in the shoots, but no ECS was detected in the roots of transgenic plant lines. The S1ptECS gene restored full mercury tolerance and partial cadmium tolerance to the mutant and enhanced arsenate tolerance significantly beyond wild-type levels. After arsenic treatment, the root concentrations of gamma-glutamylcysteine (EC), PC2, and PC3 peptides in a S1ptECS-complemented cad2-1 line increased 6- to 100-fold over the mutant levels and were equivalent to wild-type concentrations. The shoot and root levels of glutathione were 2- to 5-fold above those in wild-type plants, with or without treatment with toxicants. Thus, EC and perhaps glutathione are efficiently transported from shoots to roots. The possibility that EC or other PC pathway intermediates may act as carriers for the long-distance phloem transport and subsequent redistribution of thiol-reactive toxins and nutrients in plants is discussed.
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