ArticleThe Journal of physiology2006
Tyrosine kinase and phosphatase regulation of slow delayed-rectifier K+ current in guinea-pig ventricular myocytes.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- The association between tyrosine kinase inhibitors and fatal arrhythmia in patients with non-small cell lung cancer in Taiwan.Frontiers in oncology · 2023Article
- Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.The Journal of physiology · 2017Article
- Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: involvement of Ca2+/calmodulin binding sites.Molecules and cells · 2014Article
- Imatinib has the potential to exert its antileukemia effects by down-regulating hERG1 K+ channels in chronic myelogenous leukemia.Medical oncology (Northwood, London, England) · 2012Article
- Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium K(IR)2.3 channel, stably expressed in HEK 293 cells.British journal of pharmacology · 2011Article
- The life and death of breast cancer cells: proposing a role for the effects of phytoestrogens on potassium channels.The Journal of membrane biology · 2011Review
- Inhibition of Kv4.3 by genistein via a tyrosine phosphorylation-independent mechanism.American journal of physiology. Cell physiology · 2011Article
- Protein tyrosine kinase involvement in learning-produced changes in Hermissenda type B photoreceptors.Journal of neurophysiology · 2009Article
- Molecular mechanism underlying Akt activation in zinc-induced cardioprotection.American journal of physiology. Heart and circulatory physiology · 2009Article
- Regulation of wild-type and mutant KCNQ1/KCNE1 channels by tyrosine kinase.Pflugers Archiv : European journal of physiology · 2009Article
- Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.British journal of pharmacology · 2008Article
- Genistein inhibits voltage-gated sodium currents in SCG neurons through protein tyrosine kinase-dependent and kinase-independent mechanisms.Pflugers Archiv : European journal of physiology · 2008Article
- Involvement of tyrosine kinase in the hyposmotic stimulation of I Ks in guinea-pig ventricular myocytes.Pflugers Archiv : European journal of physiology · 2008Article
- Stimulatory action of protein kinase C(epsilon) isoform on the slow component of delayed rectifier K+ current in guinea-pig atrial myocytes.British journal of pharmacology · 2007Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to investigate the involvement of tyrosine phosphorylation in the regulation of the cardiac slowly activating delayed-rectifier K(+) current (I(Ks)) that is important for action potential repolarization. Constitutive I(Ks) recorded from guinea-pig ventricular myocytes was suppressed by broad-spectrum tyrosine kinase (TK) inhibitors tyrphostin A23 (IC(50), 4.1+/-0.6 microm), tyrphostin A25 (IC(50), 12.1+/-2.1 microm) and genistein (IC(50), 64+/-4 microm), but was relatively insensitive to the inactive analogues tyrphostin A1, tyrphostin A63, daidzein and genistin. I(Ks) was unaffected by AG1478 (10 microm), an inhibitor of epidermal growth factor receptor TK, and was strongly suppressed by the Src TK inhibitor PP2 (10 microm) but not by the inactive analogue PP3 (10 microm). The results of experiments with forskolin, H89 and bisindolylmaleimide I indicate that the suppression of I(Ks) by TK inhibitors was not mediated via inhibition of (I(Ks)-stimulatory) protein kinases A and C. To evaluate whether the suppression was related to lowered tyrosine phosphorylation, myocytes were pretreated with TK inhibitors and then exposed to the phosphotyrosyl phosphatase inhibitor orthovanadate (1 mm). Orthovanadate almost completely reversed the suppression of I(Ks) induced by broad-spectrum TK inhibitors at concentrations around their IC(50) values. We conclude that basal I(Ks) is strongly dependent on tyrosine phosphorylation of Ks channel (or channel-regulatory) protein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.