ArticleThe Journal of physiology2006
Topographical heterogeneity of K(IR) currents in pericyte-containing microvessels of the rat retina: effect of diabetes.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- Distinct potassium channel types in brain capillary pericytes.Biophysical journal · 2024Article
- Variability of Vascular Reactivity in the Retina and Choriocapillaris to Oxygen and Carbon Dioxide Using Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2023Article
- Inward rectifier potassium (Kir) channels in the retina: living our vision.American journal of physiology. Cell physiology · 2022Review
- Article
- The role of pericytes in hyperemia-induced capillary de-recruitment following stenosis.Current tissue microenvironment reports · 2020Article
- The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes.Frontiers in cellular neuroscience · 2020Review
- Synchrony of spontaneous CaJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2020Review
- Role of KPflugers Archiv : European journal of physiology · 2019Article
- Role of capillary pericytes in the integration of spontaneous CaThe Journal of physiology · 2018Article
- Role of ion channels in the functional response of conjunctival goblet cells to dry eye.American journal of physiology. Cell physiology · 2018Article
- Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies.Journal of visualized experiments : JoVE · 2018Article
- The physiological functions of central nervous system pericytes and a potential role in pain.F1000Research · 2018Review
- Article
- Capillary KNature neuroscience · 2017Article
- Boosting the signal: Endothelial inward rectifier KMicrocirculation (New York, N.Y. : 1994) · 2017Review
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth.Advances in pharmacology (San Diego, Calif.) · 2017Review
- Bioelectric impact of pathological angiogenesis on vascular function.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Ion channel networks in the control of cerebral blood flow.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Review
- Vascular inward rectifier K+ channels as external K+ sensors in the control of cerebral blood flow.Microcirculation (New York, N.Y. : 1994) · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although inwardly rectifying potassium (K(IR)) channels are known to have important functional roles in arteries and arterioles, knowledge of these channels in pericyte-containing microvessels is limited. A working hypothesis is that K(IR) channel activity affects the membrane potential and thereby the contractile tone of abluminal pericytes whose contractions and relaxations may regulate capillary perfusion. Because pericyte function is thought to be particularly important in the retina, we used the perforated-patch technique to monitor the ionic currents of pericytes located on microvessels freshly isolated from the rat retina. In addition, because changes in ion channel function may contribute to microvascular dysfunction in the diabetic retina, we also recorded from pericyte-containing microvessels of streptozotocin-injected rats. Using barium to identify K(IR) currents, we found that there is a topographical heterogeneity of these currents in the pericyte-containing microvasculature of the normal retina. Specifically, the K(IR) current detected at distal locations is strongly rectifying, but the proximal K(IR) current is weakly rectifying and has a smaller inward conductance. However, soon after the onset of diabetes, these differences diminish as the rectification and inward conductance of the proximal K(IR) current increase. These diabetes-induced changes were reversed by an inhibitor of polyamine synthesis and could be mimicked by spermine, whose concentration is elevated in the diabetic eye. Hence, spermine is a candidate for mediating the effect of diabetes on the function of microvascular K(IR) channels. In addition, our findings raise the possibility that functional changes in K(IR) channels contribute to blood flow dysregulation in the diabetic retina.
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Registered trials
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