ArticleBiophysical journal2006
Analysis of a generic model of eukaryotic cell-cycle regulation.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Who cites it
91 citing papers in PubMed, 255 citations in OpenAlex.
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- Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt.eLife · 2023Article
- A model of replicating coupled oscillators generates naturally occurring cell networks.Development (Cambridge, England) · 2023Article
- Stability analysis of a multiscale model of cell cycle dynamics coupled with quiescent and proliferating cell populations.PloS one · 2023Article
- Quantitative models for building and growing fated small cell networks.Interface focus · 2022Review
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- Cyclin/Forkhead-mediated coordination of cyclin waves: an autonomous oscillator rationalizing the quantitative model of Cdk control for budding yeast.NPJ systems biology and applications · 2021Review
- A modular approach for modeling the cell cycle based on functional response curves.PLoS computational biology · 2021Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mapping parameter spaces of biological switches.PLoS computational biology · 2021Article
- The transcriptome dynamics of single cells during the cell cycle.Molecular systems biology · 2020Article
- Developmental function and state transitions of a gene expression oscillator in Caenorhabditis elegans.Molecular systems biology · 2020Article
- Random Parametric Perturbations of Gene Regulatory Circuit Uncover State Transitions in Cell Cycle.iScience · 2020Article
- Bayesian inference using qualitative observations of underlying continuous variables.Bioinformatics (Oxford, England) · 2020Article
31 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We propose a protein interaction network for the regulation of DNA synthesis and mitosis that emphasizes the universality of the regulatory system among eukaryotic cells. The idiosyncrasies of cell cycle regulation in particular organisms can be attributed, we claim, to specific settings of rate constants in the dynamic network of chemical reactions. The values of these rate constants are determined ultimately by the genetic makeup of an organism. To support these claims, we convert the reaction mechanism into a set of governing kinetic equations and provide parameter values (specific to budding yeast, fission yeast, frog eggs, and mammalian cells) that account for many curious features of cell cycle regulation in these organisms. Using one-parameter bifurcation diagrams, we show how overall cell growth drives progression through the cell cycle, how cell-size homeostasis can be achieved by two different strategies, and how mutations remodel bifurcation diagrams and create unusual cell-division phenotypes. The relation between gene dosage and phenotype can be summarized compactly in two-parameter bifurcation diagrams. Our approach provides a theoretical framework in which to understand both the universality and particularity of cell cycle regulation, and to construct, in modular fashion, increasingly complex models of the networks controlling cell growth and division.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.