ArticleBiophysical journal2006
Cell orientation by a microgrooved substrate can be predicted by automatic control theory.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A Statistical Mechanics Approach to Describe Cell Reorientation Under Stretch.Bulletin of mathematical biology · 2023Article
- Surface engineering and the application of laser-based processes to stents - A review of the latest development.Bioactive materials · 2022Review
- Feedback-controlled dynamics of neuronal cells on directional surfaces.Biophysical journal · 2022Article
- Neuronal Growth and Formation of Neuron Networks on Directional Surfaces.Biomimetics (Basel, Switzerland) · 2021Article
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- Restoring functional neurofibromin by protein transduction.Scientific reports · 2018Article
- Intermediate filament reorganization dynamically influences cancer cell alignment and migration.Scientific reports · 2017Article
- A Unidirectional Cell Switching Gate by Engineering Grating Length and Bending Angle.PloS one · 2016Article
- Nano- and microstructured materials for in vitro studies of the physiology of vascular cells.Beilstein journal of nanotechnology · 2016Review
- Architecture and migration of an epithelium on a cylindrical wire.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Cell microenvironment engineering and monitoring for tissue engineering and regenerative medicine: the recent advances.BioMed research international · 2014Review
- Partial Blindness to Submicron Topography in NF1 Haploinsufficient Cultured Fibroblasts Indicates a New Function of Neurofibromin in Regulation of Mechanosensoric.Molecular syndromology · 2012Article
- Orientation and polarity in collectively migrating cell structures: statics and dynamics.Biophysical journal · 2011Article
- Velocity fields in a collectively migrating epithelium.Biophysical journal · 2010Article
- Engineering substrate topography at the micro- and nanoscale to control cell function.Angewandte Chemie (International ed. in English) · 2009Review
- Two characteristic regimes in frequency-dependent dynamic reorientation of fibroblasts on cyclically stretched substrates.Biophysical journal · 2008Article
- Combined effects of microtopography and cyclic strain on vascular smooth muscle cell orientation.Journal of biomechanics · 2008Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells have the ability to measure and respond to extracellular signals like chemical molecules and topographical surface features by changing their orientation. Here, we examined the orientation of cultured human melanocytes exposed to grooved topographies. To predict the cells' orientation response, we describe the cell behavior with an automatic controller model. The predicted dependence of the cell response to height and spatial frequency of the grooves is obtained by considering the symmetry of the system (cell + substrate). One basic result is that the automatic controller responds to the square of the product of groove height and spatial frequency or to the aspect ratio for symmetric grooves. This theoretical prediction was verified by the experiments, in which melanocytes were exposed to microfabricated poly(dimethylsiloxane) substrates having parallel rectangular grooves of heights (h) between 25 and 200 nm and spatial frequencies (L) between 100 and 500 mm(-1). In addition, the model of the cellular automatic controller is extended to include the case of different guiding signals acting simultaneously.
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