ArticleBiophysical journal2006
Characterization of two oxidatively modified phospholipids in mixed monolayers with DPPC.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Membrane Dynamics and Cation Handling in Ferroptosis.Physiology (Bethesda, Md.) · 2024Review
- Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis.Science advances · 2022Article
- What Does Time-Dependent Fluorescence Shift (TDFS) in Biomembranes (and Proteins) Report on?Frontiers in chemistry · 2021Review
- Investigation on the Interactions between Self-Assembled β-Sheet Peptide Nanofibers and Model Cell Membranes.International journal of molecular sciences · 2020Article
- An Increase of Oxidized Phospholipids and the Role of Macrophages in Intraocular Inflammation.Investigative ophthalmology & visual science · 2020Article
- Role of Oxidized Lipids in Permeation of HScientific reports · 2019Article
- Cholesterol Protects the Oxidized Lipid Bilayer from Water Injury: An All-Atom Molecular Dynamics Study.The Journal of membrane biology · 2018Article
- The effect of oxidized phospholipids on phenotypic polarization and function of macrophages.Free radical biology & medicine · 2017Review
- The Effects of the Structure and Composition of the Hydrophobic Parts of Phosphatidylcholine-Containing Systems on Phosphatidylcholine Oxidation by Ozone.The Journal of membrane biology · 2017Article
- Membrane Oxidation in Cell Delivery and Cell Killing Applications.ACS chemical biology · 2017Review
- Preferential hydrolysis of truncated oxidized glycerophospholipids by lysosomal phospholipase A2.Journal of lipid research · 2017Article
- Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids.Biophysical journal · 2017Article
- Effects of cardiolipin on membrane morphology: a Langmuir monolayer study.Biophysical journal · 2015Article
- Low levels of lipid oxidation radically increase the passive permeability of lipid bilayers.Soft matter · 2015Article
- Physicochemical aspects of reaction of ozone with galactolipid and galactolipid-tocopherol layers.The Journal of membrane biology · 2014Article
- Membrane changes under oxidative stress: the impact of oxidized lipids.Biophysical reviews · 2014Review
- Role of phospholipid oxidation products in atherosclerosis.Circulation research · 2012Review
- Oxidized phosphatidylcholines promote phase separation of cholesterol-sphingomyelin domains.Biophysical journal · 2012Article
- Oxidized phosphatidylcholines facilitate phospholipid flip-flop in liposomes.Biophysical journal · 2011Article
- Cholesterol slows down the lateral mobility of an oxidized phospholipid in a supported lipid bilayer.Langmuir : the ACS journal of surfaces and colloids · 2010Article
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4 authors.
Funding
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Abstract
The properties of two oxidatively modified phospholipids viz. 1-palmitoyl-2-(9'-oxo-nonanoyl)-sn-glycero-3-phosphocholine (PoxnoPC) and 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PazePC), were investigated using a Langmuir balance, recording force-area (pi-A) isotherms and surface potential psi. In mixed monolayers with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) a progressive disappearance of the liquid expanded-liquid condensed transition and film expansion was observed with increasing content of the oxidized phospholipids. The above is in agreement with fluorescence microscopy of the monolayers, which revealed an increase in the liquid expanded region of DPPC monolayers. At a critical pressure pi(s) approximately 42 mN/m both Poxo- and PazePC induced a deflection in the pi-A isotherms, which could be rationalized in terms of reorientation of the oxidatively modified acyl chains into aqueous phase (adaptation of the so-called extended conformation), followed upon further film compression by solubilization of the oxidized phospholipids into the aqueous phase. Surface potential displayed a discontinuity at the same value of area/molecule, corresponding to the loss of the oxidized phospholipids from the monolayers. Our data support the view that lipid oxidation modifies both the small-scale structural dynamics of biological membranes as well as their more macroscopic lateral organization. Accordingly, oxidatively modified lipids can be expected to influence the organization and functions of membrane associated proteins.
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