ArticleMolecular and cellular biology2006
An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 77 citations in OpenAlex.
- Interplay and cooperation between GLI2 and master transcription factors promote progression of esophageal squamous cell carcinoma.American journal of human genetics · 2025Article
- Interaction between MED12 and ΔNp63 activates basal identity in pancreatic ductal adenocarcinoma.Nature genetics · 2024Article
- Identification of HTRA4 as a Transcriptional Target of p63 in Trophoblast.The American journal of pathology · 2024Article
- Marker-based CRISPR screening reveals a MED12-p63 interaction that activates basal identity in pancreatic ductal adenocarcinoma.bioRxiv : the preprint server for biology · 2023Article
- Oncogenic YAP mediates changes in chromatin accessibility and activity that drive cell cycle gene expression and cell migration.Nucleic acids research · 2023Article
- EZH2 regulates a SETDB1/ΔNp63α axis via RUNX3 to drive a cancer stem cell phenotype in squamous cell carcinoma.Oncogene · 2022Article
- Interaction of the NRF2 and p63 transcription factors promotes keratinocyte proliferation in the epidermis.Nucleic acids research · 2021Article
- Super-enhancer-mediated core regulatory circuitry in human cancer.Computational and structural biotechnology journal · 2021Review
- Long-term expansion of directly reprogrammed keratinocyte-like cells and in vitro reconstitution of human skin.Journal of biomedical science · 2020Article
- Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells.EMBO molecular medicine · 2020Article
- SOX2 Regulates P63 and Stem/Progenitor Cell State in the Corneal Epithelium.Stem cells (Dayton, Ohio) · 2019Article
- A toolbox to study epidermal cell types in zebrafish.Journal of cell science · 2017Article
- Reciprocal interplay between thyroid hormone and microRNA-21 regulates hedgehog pathway-driven skin tumorigenesis.The Journal of clinical investigation · 2016Article
- Pathway Regulation of p63, a Director of Epithelial Cell Fate.Frontiers in endocrinology · 2015Review
- A composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms.Nucleic acids research · 2015Article
- Regulatory network decoded from epigenomes of surface ectoderm-derived cell types.Nature communications · 2014Article
- A mutation in TP63 causing a mild ectodermal dysplasia phenotype.The Journal of investigative dermatology · 2014Article
- Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress.Nucleic acids research · 2014Article
- S100A2 is a BRCA1/p63 coregulated tumour suppressor gene with roles in the regulation of mutant p53 stability.Cell death & disease · 2014Article
- An Intimate Relationship between Thyroid Hormone and Skin: Regulation of Gene Expression.Frontiers in endocrinology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
p63, a p53 family member, is essential for the development of various stratified epithelia and is one of the earliest markers of many ectodermal structures, including the epidermis, oral mucosa, apical ectodermal ridge, and mammary gland. Genetic regulatory mechanisms controlling p63 spatial expression during development have not yet been defined. Using a genomic approach, we identified an evolutionarily conserved cis-regulatory element, located 160 kb downstream of the first p63 exon, which functions as a keratinocyte-specific enhancer and is sufficient to recapitulate expression of the endogenous gene during mouse embryogenesis. Dissection of the p63 enhancer activity revealed a positive autoregulatory loop in which the p63 proteins directly bind to and are essential regulators of the enhancer. Accordingly, transactivating p63 isoforms induce endogenous p63 expression in cells that do not normally express this gene, whereas dominant negative isoforms suppress p63 expression in keratinocytes. In addition the transcription factor AP-2 also binds to the enhancer and cooperates with p63 to induce its activity. These results demonstrate that a long-range autoregulatory loop is involved in the regulation of p63 expression during embryonic development and in adult cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.