ArticleMolecular and cellular biology2006
CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 58 citations in OpenAlex.
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- Article
- ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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- RB Regulates DNA Double Strand Break Repair Pathway Choice by Mediating CtIP Dependent End Resection.International journal of molecular sciences · 2020Article
- USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP.Nature communications · 2020Article
- PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks.Nucleic acids research · 2020Article
- ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection.PLoS genetics · 2020Article
- The CTIP-mediated repair of TNF-α-induced DNA double-strand break was impaired by miR-130b in cervical cancer cell.Cell biochemistry and function · 2019Article
- CtIP is essential for early B cell proliferation and development in mice.The Journal of experimental medicine · 2019Article
- The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression.Oncogene · 2017Article
- Exome-capture RNA sequencing of decade-old breast cancers and matched decalcified bone metastases.JCI insight · 2017Article
- Contextualizing the Genes Altered in Bladder Neoplasms in Pediatric andTeen Patients Allows Identifying Two Main Classes of Biological ProcessesInvolved and New Potential Therapeutic Targets.Current genomics · 2016Article
- SERBP1 affects homologous recombination-mediated DNA repair by regulation of CtIP translation during S phase.Nucleic acids research · 2015Article
- CtIP tetramer assembly is required for DNA-end resection and repair.Nature structural & molecular biology · 2015Article
- When two is not enough: a CtIP tetramer is required for DNA repair by Homologous Recombination.Nucleus (Austin, Tex.) · 2015Article
- Trichomide A, a natural cyclodepsipeptide, exerts immunosuppressive activity against activated T lymphocytes by upregulating SHP2 activation to overcome contact dermatitis.The Journal of investigative dermatology · 2014Article
- 53BP1, BRCA1, and the choice between recombination and end joining at DNA double-strand breaks.Molecular and cellular biology · 2014Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cell cycle progression from G(1) to S phase is mainly controlled by E2F transcription factors and RB family proteins. Previously we showed that the presence of CtIP is essential for G(1)/S transition in primary mouse blastocysts, as well as in NIH 3T3 cells. However, how CtIP executes this function remains to be elucidated. Here we show that in NIH 3T3 cells the expression of CtIP is regulated by the E2F/RB pathway during late G(1) and S phases. The presence of wild-type CtIP, but not the E157K mutant form, which failed to interact with RB, enhanced its own promoter activity. Chromatin immunoprecipitation analysis indicated that the recruitment of CtIP to its promoter occurs concomitantly with TFIIB, a component of the RNA polymerase II complex, and with dissociation of RB from the promoter during late G(1) and G(1)/S transition. Similar positive regulation of cyclin D1 expression by CtIP was also observed. Consistently, cells expressing the CtIP(E157K) protein alone exhibited growth retardation, an increase in the G(1) population, and a decrease in the S-phase population. Taken together, these results suggest that, contrary to the postulated universal corepressor role, CtIP activates a subset of E2F-responsive promoters by releasing RB-imposed repression and therefore promotes G(1)/S progression.
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