ArticleCell metabolism2006
Zebrafish fat-free is required for intestinal lipid absorption and Golgi apparatus structure.
Article in Cell metabolism, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 60 citations in OpenAlex.
- Zebrafish as a Model for Cardiovascular and Metabolic Disease: The Future of Precision Medicine.Biomedicines · 2024Review
- Review
- Vps54 regulatesBiology open · 2020Article
- Maintaining order: COG complex controls Golgi trafficking, processing, and sorting.FEBS letters · 2019Review
- A neurodevelopmental disorder caused by mutations in the VPS51 subunit of the GARP and EARP complexes.Human molecular genetics · 2019Article
- The rare mutation in the endosome-associated recycling protein geneMolecular cytogenetics · 2019Article
- LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.Physiological reviews · 2017Review
- An HPLC-CAD/fluorescence lipidomics platform using fluorescent fatty acids as metabolic tracers.Journal of lipid research · 2017Article
- Lipid Uptake, Metabolism, and Transport in the Larval Zebrafish.Frontiers in endocrinology · 2017Review
- Using fluorescent lipids in live zebrafish larvae: From imaging whole animal physiology to subcellular lipid trafficking.Methods in cell biology · 2016Article
- Zebrafish: an important tool for liver disease research.Gastroenterology · 2015Review
- A high-throughput assay for quantifying appetite and digestive dynamics.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Disruption of ldlr causes increased LDL-c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia.Journal of lipid research · 2014Article
- Zebrafish yolk lipid processing: a tractable tool for the study of vertebrate lipid transport and metabolism.Disease models & mechanisms · 2014Article
- Zebrafish models of dyslipidemia: relevance to atherosclerosis and angiogenesis.Translational research : the journal of laboratory and clinical medicine · 2014Review
- The emerging use of zebrafish to model metabolic disease.Disease models & mechanisms · 2013Review
- Zebrafish models of human liver development and disease.Comprehensive Physiology · 2013Review
- Imaging vertebrate digestive function and lipid metabolismDrug discovery today. Disease models · 2013Article
- Emerging applications for zebrafish as a model organism to study oxidative mechanisms and their roles in inflammation and vascular accumulation of oxidized lipids.Free radical biology & medicine · 2012Review
- Visualization of lipid metabolism in the zebrafish intestine reveals a relationship between NPC1L1-mediated cholesterol uptake and dietary fatty acid.Chemistry & biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The zebrafish fat-free (ffr) mutation was identified in a physiological screen for genes that regulate lipid metabolism. ffr mutant larvae are morphologically indistinguishable from wild-type sibling larvae, but their absorption of fluorescent lipids is severely impaired. Through positional cloning, we have identified a causative mutation in a highly conserved and ubiquitously expressed gene within the ffr locus. The Ffr protein contains a Dor-1 like domain typical of oligomeric Golgi complex (COG) gene, cog8. Golgi complex ultrastructure is disrupted in the ffr digestive tract. Consistent with a possible role in COG-mediated Golgi function, wild-type Ffr-GFP and COG8-mRFP fusion proteins partially colocalize in zebrafish blastomeres. Enterocyte retention of an endosomal lipid marker in ffr larvae support the idea that altered vesicle trafficking contributes to the ffr mutant defect. These data indicate that ffr is required for both Golgi structure and vesicular trafficking, and ultimately lipid transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.