ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Worsening of left ventricular ejection fraction induced by dipyridamole on Tl-201 gated myocardial perfusion imaging predicts significant coronary artery disease.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Prognostic significance of non-perfusion parameters of cadmium-zinc-telluride single-photon emission computed tomography myocardial perfusion imaging for individuals with normal myocardial perfusion: a large-scale single-center retrospective cohort study.Annals of nuclear medicine · 2025Article
- Implications of transient ischemic dilatation and impaired left ventricular ejection fraction reserve in patients with normal stress myocardial perfusion imaging and elevated coronary artery calcium.The international journal of cardiovascular imaging · 2022Article
- Left ventricular ejection fraction, myocardial blood flow and hemodynamic variables in adenosine and regadenoson vasodilator 82-Rubidium PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Optimizing diagnosis and risk stratification of ischemic heart disease by myocardial perfusion imaging: The incremental values of non-perfusion variables during vasodilator stress.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Comparison of left ventricular mechanical dyssynchrony parameters between exercise and adenosine triphosphate stress tests using gated single-photon emission computed tomography myocardial perfusion imaging.Kardiologia polska · 2021Article
- A perfect tool for comprehensive evaluation of myocardial perfusion and function: Stress PET imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Do we need a new definition for post-stress reduction in LVEF beyond the numerical values?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Myocardial stunning by gated SPECT: An old tool reinvented in a stunning turn.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- The significance of post-stress decrease in left ventricular ejection fraction in patients undergoing regadenoson stress gated SPECT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Assessment of left ventricular ejection fraction reserve in an era of decreasing frequency of myocardial ischemia during myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Thallium-201 is comparable to technetium-99m-sestamibi for estimating cardiac function in patients with abnormal myocardial perfusion imaging.The Kaohsiung journal of medical sciences · 2015Article
- Relation of early post-stress left ventricular dyssynchrony and the extent of angiographic coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- The relationship between ischemia-induced left ventricular dysfunction, coronary flow reserve, and coronary steal on regadenoson stress-gated (82)Rb PET myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
- Diagnosing CAD: additional markers from myocardial perfusion SPECT.Journal of biomedical research · 2013Review
- Prognostic Value of Functional Variables as Assessed by Gated Thallium-201 Myocardial Perfusion Single Photon Emission Computed Tomography for Major Adverse Cardiac Events in Patients with Coronary Artery Disease.Acta Cardiologica Sinica · 2013Article
- Left-ventricular dyssynchrony evaluated by Tl-201 gated SPECT myocardial perfusion imaging: a comparison with Tc-99m sestamibi.Nuclear medicine communications · 2013Article
- Stress-induced myocardial ischemia is associated with early post-stress left ventricular mechanical dyssynchrony as assessed by phase analysis of 201Tl gated SPECT myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2012Article
- Single photon emission computed tomography for the diagnosis of coronary artery disease: an evidence-based analysis.Ontario health technology assessment series · 2010Article
- Determinants of the response of left ventricular ejection fraction to vasodilator stress in electrocardiographically gated (82)rubidium myocardial perfusion PET.European journal of nuclear medicine and molecular imaging · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVasodilator stress on myocardial perfusion imaging has been found to induce ischemic stunning, which may present as transient worsening of left ventricular ejection fraction (LVEF) or regional wall motion abnormality. This study aimed to evaluate the significance of stress-induced worsening of LVEF in the diagnosis of coronary artery disease (CAD) on dipyridamole thallium 201 gated single photon emission computed tomography (SPECT). METHODS AND
resultsThe study included 126 patients who underwent dipyridamole Tl-201 gated SPECT and coronary angiography within 3 months. Poststress and 4-hour rest images were obtained, and LVEF was calculated by use of automated software (QGS 3.0). A decrease in LVEF of 6% or greater from rest to poststress was considered significant, and this threshold was determined by the serial reproducibility assessment of Tl-201 gated SPECT. If worsening of LVEF was used as the criterion for detecting significant CAD (> or = 70% coronary stenoses in > or = 1 vessel), the sensitivity, specificity, positive predictive value, and negative predictive value were 35%, 93%, 90%, and 44%, respectively.
conclusionDipyridamole-induced worsening of LVEF, as shown by Tl-201 gated SPECT, is a valuable nonperfusion marker of significant CAD. Although the sensitivity of LVEF worsening in detecting significant CAD is only 35%, the specificity is as high as 93%.
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