ReviewDrug discovery today2006
Keynote review: allosterism in membrane receptors.
Review in Drug discovery today, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Potentiation of insulin-mediated glucose lowering without elevated hypoglycemia risk by a small molecule insulin receptor modulator.PloS one · 2015Article
- The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor.Structure (London, England : 1993) · 2013Article
- Structure-function of the G protein-coupled receptor superfamily.Annual review of pharmacology and toxicology · 2013Review
- Allosteric modulation and functional selectivity of G protein-coupled receptors.Drug discovery today. Technologies · 2013Review
- Protection from myocardial ischemia/reperfusion injury by a positive allosteric modulator of the A₃ adenosine receptor.The Journal of pharmacology and experimental therapeutics · 2012Article
- The different ways through which specificity works in orthosteric and allosteric drugs.Current pharmaceutical design · 2012Article
- Diversity and modularity of G protein-coupled receptor structures.Trends in pharmacological sciences · 2012Review
- The significance of G protein-coupled receptor crystallography for drug discovery.Pharmacological reviews · 2011Review
- Functionally biased modulation of A(3) adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers.Biochemical pharmacology · 2011Article
- Activation and regulation of purinergic P2X receptor channels.Pharmacological reviews · 2011Review
- Rational design of dualsteric GPCR ligands: quests and promise.British journal of pharmacology · 2010Review
- Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor.Journal of medicinal chemistry · 2009Article
- Allosteric modulation of adenosine receptors.Purinergic signalling · 2009Article
- Multiple Ca(2+)-binding sites in the extracellular domain of the Ca(2+)-sensing receptor corresponding to cooperative Ca(2+) response.Biochemistry · 2009Article
- Conformational changes in alpha 7 acetylcholine receptors underlying allosteric modulation by divalent cations.BMC pharmacology · 2009Article
- Flexible modulation of agonist efficacy at the human A3 adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000.BMC pharmacology · 2008Article
- CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer.The Biochemical journal · 2008Article
- Competitive and noncompetitive odorant interactions in the early neural coding of odorant mixtures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Coarse-grained free energy functions for studying protein conformational changes: a double-well network model.Biophysical journal · 2007Article
- An HSV vector system for selection of ligand-gated ion channel modulators.Nature methods · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Allosteric modulation of membrane receptors has been intensively studied in the past three decades and is now considered to be an important indirect mechanism for the control of receptor function. The allosteric site on the GABA(A) receptor is the target for the most widely prescribed sleep medicines, the benzodiazepines. Cinacalcet, an allosteric enhancer of the calcium-sensing receptor, is used to treat secondary hyperparathyroidism. Allosteric ligands might be especially valuable to control receptors for which the design of selective orthosteric agonists or antagonists has been elusive, such as muscarinic acetylcholine receptors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.