Evidence map›Paper›PMID 16580519›Full record

ReviewJournal of the American College of Cardiology2006

Regionalization of ST-segment elevation acute coronary syndromes care: putting a national policy in proper perspective.

Saif S Rathore, Andrew J Epstein, Brahmajee K Nallamothu, Harlan M Krumholz

Open access · greenAbstract readReview
In one paragraph

Review in Journal of the American College of Cardiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Guideline
  2. Differential benefits of cardiac care regionalization based on driving time to percutaneous coronary intervention.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Quality of care for acute myocardial infarction in 58 U.S. emergency departments.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2010
    Article
  9. The neurointerventional bubble.AJNR. American journal of neuroradiology · 2010
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Saif S RathoreSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Andrew J Epstein
Brahmajee K Nallamothu
Harlan M Krumholz
Yale University · USHealth Services Research & Development · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Michigan Mentored Clinical Scholars ProgramK12RR017607 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHTEINGART, DAVID EDUARDO · 2003 to 2007
$3.0M
Strategies to reduce time to reperfusion therapy for MIR01HL072575 · NHLBI · YALE UNIVERSITY · PI KRUMHOLZ, HARLAN MARC · 2003 to 2005
$2.3M
NCRR NIH HHS K12 RR017607NCRR NIH HHS K12 RR017607-01NHLBI NIH HHS R01 HL072575NIGMS NIH HHS GM07025NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

A uniform policy for regionalization of ST-segment elevation myocardial infarction (STEMI) care raises several concerns. Transferring all STEMI patients to obtain primary percutaneous coronary intervention (PCI) may be less effective than transferring only high-risk STEMI patients. Delays in time to treatment >60 min associated with transferring patients for primary PCI may result in increased mortality for the average patient as compared with providing immediate fibrinolytic therapy at their initial hospital; yet more than 95% of patients transferred for primary PCI in the U.S. exceed this 60-min benchmark. Superior outcomes associated with treatment at higher-volume regional STEMI centers are inconsistent among centers, and there is no direct evidence that patients will benefit by a transfer to a high-volume hospital from a low-volume hospital. Published data suggest as many as 800 PCI patients would need to be transferred to a high-volume PCI hospital to avoid a single death at a low-volume PCI hospital. Although European randomized trial data suggest transferring patients with STEMI for primary PCI may be superior to immediate fibrinolytic therapy, these findings are unlikely to generalize to the U.S. health care system given size, geography, and organization. ST segment elevation myocardial infarction care regionalization would require a massive redistribution of health care resources, depriving several hospitals of advanced cardiac care facilities, expertise, and associated revenue. Clearer evidence of the benefits and discussion of potential harms are needed before adopting a national STEMI regionalization policy.

Indexed as

ElectrocardiographyHealth PolicyAcute DiseaseCoronary DiseaseHumansSyndrome

Identifiers

PMID16580519
PMCPMC2789345
OpenAlexW1653216255

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.