ReviewAutonomic neuroscience : basic & clinical2006
Short-term receptor trafficking in the dorsal vagal complex: an overview.
Review in Autonomic neuroscience : basic & clinical, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Fibroblast Growth Factor 19 Increases the Excitability of Pre-Motor Glutamatergic Dorsal Vagal Complex Neurons From Hyperglycemic Mice.Frontiers in endocrinology · 2021Article
- Neuromechanism of acupuncture regulating gastrointestinal motility.World journal of gastroenterology · 2020Review
- Characterization of the Basic Membrane Properties of Neurons of the Rat Dorsal Motor Nucleus of the Vagus in Paraquat-Induced Models of Parkinsonism.Neuroscience · 2019Article
- Vagally mediated effects of brain stem dopamine on gastric tone and phasic contractions of the rat.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Ameliorating effects of auricular electroacupuncture on rectal distention-induced gastric dysrhythmias in rats.PloS one · 2015Article
- Exposure to a high fat diet during the perinatal period alters vagal motoneurone excitability, even in the absence of obesity.The Journal of physiology · 2015Article
- Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions.Comprehensive Physiology · 2014Review
- cAMP-dependent insulin modulation of synaptic inhibition in neurons of the dorsal motor nucleus of the vagus is altered in diabetic mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Vagal afferent fibres determine the oxytocin-induced modulation of gastric tone.The Journal of physiology · 2013Article
- Interactions between epinephrine, ascending vagal fibers, and central noradrenergic systems in modulating memory for emotionally arousing events.Frontiers in behavioral neuroscience · 2012Article
- Vanilloid, purinergic, and CCK receptors activate glutamate release on single neurons of the nucleus tractus solitarius centralis.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Opioidergic consequences of dietary-induced binge eating.Physiology & behavior · 2011Article
- Plasticity of vagal brainstem circuits in the control of gastrointestinal function.Autonomic neuroscience : basic & clinical · 2011Review
- Differential organization of excitatory and inhibitory synapses within the rat dorsal vagal complex.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Plasticity of vagal brainstem circuits in the control of gastric function.Neurogastroenterology and motility · 2010Article
- Mechanisms of Broad-Spectrum Antiemetic Efficacy of Cannabinoids against Chemotherapy-Induced Acute and Delayed Vomiting.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Modulation of inhibitory neurotransmission in brainstem vagal circuits by NPY and PYY is controlled by cAMP levels.Neurogastroenterology and motility · 2009Article
- Vagally mediated effects of glucagon-like peptide 1: in vitro and in vivo gastric actions.The Journal of physiology · 2009Article
- Effects of brain stem cholecystokinin-8s on gastric tone and esophageal-gastric reflex.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Hindbrain Effects of L-Glutamate on Gastric Motility in Rats.Gastroenterology research · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sensory information from the gastrointestinal (GI) tract is transmitted centrally via primary afferents that terminate within the nucleus of the tractus solitarius (NTS) and utilize glutamate as their major neurotransmitter. Neurons of the NTS integrate this sensory information and transmit it to parasympathetic preganglionic neurons of the dorsal motor nucleus of the vagus (DMV), as well as to other areas, using principally glutamate, GABA and norepinephrine as neurotransmitters. Although susceptible to modulation by a vast array of neurotransmitters, the glutamatergic NTS to DMV synapse seems to play a minor role in the tonic modulation of gastric vagal reflexes. GABAergic neurotransmission between the NTS and DMV, however, is of critical importance as its in vivo blockade induces dramatic effects on gastric tone, motility and secretion. In in vitro experiments, however, this synapse appears initially resistant to modulation by most exogenously applied neuromodulators. Using opioid peptides as a model, this review will discuss the remarkable plasticity of the NTS-DMV GABAergic synapse. Modulation of this synapse appears dependent upon the levels of cAMP within the brainstem circuit. In particular, this review will outline how vagal afferent inputs appear to dampen the cAMP-PKA system via tonic activation of metabotropic glutamate receptors. Removal of vagal sensory input, coincident activation of the cAMP-PKA system, or inhibition of group II metabotropic glutamate receptors, allows receptor trafficking to occur selectively at the level of the NTS-DMV GABAergic synapse. Thus, we propose that the state of activation of vagal sensory inputs determines the gastric motor response via selective engagement of GABAergic synapses. This mini-review is based upon a presentation given at the International Society for Autonomic Neuroscience meeting in Marseille, France in July 2005.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.