ArticleCurrent allergy and asthma reports2006
Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population.
Article in Current allergy and asthma reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma.American journal of respiratory cell and molecular biology · 2025Pooled it
- Systematic review reveals multiple sexually antagonistic polymorphisms affecting human disease and complex traits.Evolution; international journal of organic evolution · 2021Pooled it
- Rising prevalence of asthma is sex-specific in a US farming population.The Journal of allergy and clinical immunology · 2011Trial
- The CRTh2 polymorphism rs533116 G > A associates with asthma severity in older females.Frontiers in medicine · 2022Article
- Extension of GWAS results for lipid-related phenotypes to extreme obesity using electronic health record (EHR) data and the Metabochip.Frontiers in genetics · 2014Article
- The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.Human molecular genetics · 2012Article
- Gene-environment interactions in human disease: nuisance or opportunity?Trends in genetics : TIG · 2011Review
- Sex-specific effect of IL9 polymorphisms on lung function and polysensitization.Genes and immunity · 2009Article
- Article
- A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.The Laryngoscope · 2008Article
- Sex-specific differences in chromosome-dependent regulation of vascular reactivity in female consomic rat strains from a SSxBN cross.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- A computational model for sex-specific genetic architecture of complex traits in humans: implications for mapping pain sensitivity.Molecular pain · 2008Article
- A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age.Translational research : the journal of laboratory and clinical medicine · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Identifying genes that influence susceptibility to asthma-related and atopy-related phenotypes has been challenging, owing to clinical heterogeneity and a complex underlying genetic architecture that includes both gene-gene and gene-environment interactions. In this article, we report the results of genome-wide linkage and association studies of eight asthma-associated quantitative traits in the Hutterites, a founder population of European descent. Our study revealed significant sex-specific genetic architecture for at least five of these traits, and identified 13 genome-wide significant quantitative trait loci (QTL) by linkage or association that are present in only one of the sexes (nine in males, four in females).
Indexed as
Identifiers
16579875What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.