ArticleGenes, chromosomes & cancer2006
A genome wide linkage search for breast cancer susceptibility genes.
Article in Genes, chromosomes & cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Article
- Evaluating the Utility of ctDNA in Detecting Residual Cancer and Predicting Recurrence in Patients with Serous Ovarian Cancer.International journal of molecular sciences · 2023Article
- Rat Mammary carcinoma susceptibility 3 (Mcs3) pleiotropy, socioenvironmental interaction, and comparative genomics with orthologous human 15q25.1-25.2.G3 (Bethesda, Md.) · 2023Article
- A New de novoThe application of clinical genetics · 2023Article
- Association between single-nucleotide polymorphisms in miRNA and breast cancer risk: an updated review.Biological research · 2021Review
- The LINC01119-SOCS5 axis as a critical theranostic in triple-negative breast cancer.NPJ breast cancer · 2021Article
- BRCA and Breast Cancer-Related High-Penetrance Genes.Advances in experimental medicine and biology · 2021Review
- Article
- The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis.Breast cancer research : BCR · 2019Article
- Journey's end: the quest for BRCA-like hereditary breast cancer genes is nearly over.Annals of oncology : official journal of the European Society for Medical Oncology · 2019Article
- Bridging the Data Gap in Breast Cancer Risk Assessment to Enable Widespread Clinical Implementation across the Multiethnic Landscape of the US.Journal of cancer treatment & diagnosis · 2018Article
- Article
- Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations.Biological research · 2017Review
- Six low-penetrance SNPs for the estimation of breast cancer heritability: A family-based study in Caucasian Italian patients.Oncology letters · 2017Article
- Physical Confirmation and Comparative Genomics of the RatG3 (Bethesda, Md.) · 2017Article
- Thyroid cancer with concurrent breast tubular cancer: A case report and literature review.Cancer biomarkers : section A of Disease markers · 2017Article
- DNA methylation profiling to assess pathogenicity of BRCA1 unclassified variants in breast cancer.Epigenetics · 2015Article
- Rare mutations in RINT1 predispose carriers to breast and Lynch syndrome-spectrum cancers.Cancer discovery · 2014Article
- Familial breast cancer genetic testing in the West of Ireland.Irish journal of medical science · 2014Article
- A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium.Human molecular genetics · 2014Article
Corrections and comments
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Authors and funding
50 authors.
Funding
Abstract
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a combined analysis of four genome-wide linkage screens, which included a total of 149 multiple case breast cancer families. All families included at least three cases of breast cancer diagnosed below age 60 years, at least one of whom had been tested and found not to carry a BRCA1 or BRCA2 mutation. Evidence for linkage was assessed using parametric linkage analysis, assuming both a dominant and a recessive mode of inheritance, and using nonparametric methods. The highest LOD score obtained in any analysis of the combined data was 1.80 under the dominant model, in a region on chromosome 4 close to marker D4S392. Three further LOD scores over 1 were identified in the parametric analyses and two in the nonparametric analyses. A maximum LOD score of 2.40 was found on chromosome arm 2p in families with four or more cases of breast cancer diagnosed below age 50 years. The number of linkage peaks did not differ from the number expected by chance. These results suggest regions that may harbor novel breast cancer susceptibility genes. They also indicate that no single gene is likely to account for a large fraction of the familial aggregation of breast cancer that is not due to mutations in BRCA1 or BRCA2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.