ArticleDiabetologia2006
Increased prevalence of Down's syndrome in individuals with type 1 diabetes in Denmark: A nationwide population-based study.
Article in Diabetologia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 107 citations in OpenAlex.
- Acute kidney injury and chronic kidney disease in individuals with Down syndrome: a nationwide cohort study.Clinical kidney journal · 2026Article
- IgG1 glycosylation highlights premature aging in Down syndrome.Aging cell · 2024Article
- Down Syndrome and Autoimmune Disease.Clinical reviews in allergy & immunology · 2024Review
- Characterization of autoimmune eye disease in association with Down's syndrome.Eye (London, England) · 2024Article
- Endocrine, auxological and metabolic profile in children and adolescents with Down syndrome: from infancy to the first steps into adult life.Frontiers in endocrinology · 2024Review
- Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome.Biological research · 2023Article
- A Scoping Review of the Complementary Feeding Practices and Early Eating Experiences of Children With Down Syndrome.Journal of pediatric psychology · 2023Article
- Characterization of autoimmune eye disease in association with Down's Syndrome.Research square · 2023Article
- Prescriptions for insulin and insulin analogues in children with and without major congenital anomalies: a data linkage cohort study across six European regions.European journal of pediatrics · 2023Article
- Endocrinal dysfunction in children with Down syndrome.Annals of pediatric endocrinology & metabolism · 2022Article
- Association between perinatal factors and future risk for gout-a nested case-control study.Arthritis research & therapy · 2022Article
- Characteristics of type 1 diabetes mellitus in children and adolescents with Down's syndrome in an admixed population.Archives of endocrinology and metabolism · 2021Article
- Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes.Disease models & mechanisms · 2021Article
- Medical vulnerability of individuals with Down syndrome to severe COVID-19-data from the Trisomy 21 Research Society and the UK ISARIC4C survey.EClinicalMedicine · 2021Article
- Metabolic Diseases and Down Syndrome: How Are They Linked Together?Biomedicines · 2021Review
- Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules.Biomolecules · 2021Review
- Interferon-Driven Immune Dysregulation in Down Syndrome: A Review of the Evidence.Journal of inflammation research · 2021Review
- Early Onset of Autoimmune Diabetes in Children with Down Syndrome-Two Separate Aetiologies or an Immune System Pre-Programmed for Autoimmunity?Current diabetes reports · 2020Review
- Evaluation of biochemical and hematological parameters in adults with Down syndrome.Scientific reports · 2020Article
- Down Syndrome and COVID-19: A Perfect Storm?Cell reports. Medicine · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisIn patients with Down's syndrome, dogma has long held that the prevalence of diabetes is increased. The aim of the present study was to determine the actual prevalence of Down's syndrome among type 1 diabetic patients. SUBJECTS, MATERIALS AND
methodsThe background population included all children born in Denmark between 1981 and 2000. Registry-validated and clinical data on type 1 diabetes and Down's syndrome diagnoses were obtained from the National Disease Register and Danish Cytogenetic Central Register, respectively.
resultsThe prevalence of Down's syndrome in the background population was 0.09%, whereas we identified a prevalence of Down's syndrome in type 1 diabetes patients of 0.38% (95% CI 0.17-0.75), corresponding to a 4.2-fold increased prevalence compared with the background population (p = 7.3 x 10(-5)). CONCLUSIONS/
interpretationTo the best of our knowledge this is the first population-based study addressing the prevalence of Down's syndrome among verified type 1 diabetes patients. A more than fourfold increased prevalence of Down's syndrome among type 1 diabetes patients supports the notion that genes on chromosome 21 may confer risk for type 1 diabetes, probably also in the general population.
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